In the present study, it was found that the ruthenium (II) imidazole complex [Ru(Im)4(dppz)]2+ (Ru1) could induce significant growth inhibition and apoptosis in A549 and NCI-H460 cells. Apart from the induction of apoptosis, it was reported for the first time that Ru1 induced an autophagic response in A549 and NCI-H460 cells as evidenced by the formation of autophagosomes, acidic vesicular orga...

This study investigated the photodynamic therapy (PDT) and anticancer activity of mixed ligand Ru(ii) terpyridyl complexes (Ru1-Ru3). The photophysical and photochemical properties, hydrophobic properties, DNA binding and DNA transcription inhibition abilities, cell uptake efficiency, cellular localization and photo-cytotoxicity were investigated. Ru1-Ru3 exhibited red luminescence between 670-...

The binding of factor VIII to von Willebrand factor (vWF) is essential for the protection of factor VIII against proteolytic degradation in plasma. We have characterized the binding kinetics of human factor VIII with vWF using a centrifugation binding assay. Purified or plasma vWF was immobilized with a monoclonal antibody (MoAb RU1) covalently linked to Sepharose (Pharmacia LKB Biotechnology, ...

Ruthenium complexes have been considered as promising substitutes for cisplatin in cancer chemotherapy. However, novel ruthenium-based therapies are faced with some limitations, such as unimpressive cytotoxicity toward solid tumors. Herein, we designed and synthesized phenyl-substituted terpyridyl ruthenium(ii) complexes ([Ru(tpy)(bpy)Cl](+) (Ru1), [Ru(phtpy)(bpy)Cl](+) (Ru2) and [Ru(biphtpy)(b...

Let (RU1, RU2) be a given bivariate scale mixture random vector, with R > 0 being independent of the bivariate random vector (U1, U2). In this paper we derive exact asymptotic expansions of the tail probability P{RU1 > x, RU2 > ax}, a ∈ (0, 1] as x → ∞ assuming that R has distribution function in the Gumbel max-domain of attraction and (U1, U2) has a specific tail behaviour around some absorbin...

The uniform one-dimensional fragment U1 of first-order logic was introduced recently as a natural generalization of the two-variable fragment FO2 to contexts with relation symbols of all arities. It was shown that U1 has the exponential model property and a NExpTime-complete satisfiability problem. In this paper we investigate two restrictions of U1 that still contain FO2. We call these logics ...

Due to the specific physical and chemical properties of a highly branched noble metal, the controllable synthesis has attracted much attention. This article reports the synthesis of Pd/Ru nanodendrites by a facile method using an oil bath in the presence of polyvinyl pyrrolidone, potassium bromide and ascorbic acid. The morphology, structure, and composition of the as-prepared catalysts were ch...

ABSTRACT A strain of Bean common mosaic necrosis virus (BCMNV) from Idaho was identified by enzyme-linked immunosorbent assay using monoclonal antibodies and determined to be similar to the NL-3 D strain (of Drifjhout) by reaction of differential bean cultivars. However, this BCMNV strain (designated NL-3 K) caused earlier and more severe symptoms on bean plants representing host groups 0, 4, a...

The treatment of [Ru(η6-p-cymene)Cl2]2 with N,N’-(1,2-phenylene)dipicolinamide (H2L1) afforded the double salt complex [{Ru(η6-p-cymene)2-µ-Cl}L1][Ru(η6-p-cymene)Cl3], (Ru1) in moderate yields. Separately, reactions ligands (H2L1), N,N’-(4,5 dimethyl-1,2-phenylene)dipicolinamide (H2L2), and N,N’-(4-methoxy-1,2-phenylene)dipicolinamide (H2L3) presence KPF6 respective dinuclear half-sandwich Ru(I...

We report on the magnetic structures of ${\mathrm{Tb}}_{3}{\mathrm{RuO}}_{7}$ and ${\mathrm{Nd}}_{3}{\mathrm{RuO}}_{7}$ determined from powder neutron-diffraction experiments. In ${\mathrm{Tb}}_{3}{\mathrm{RuO}}_{7}$, alternating-bond spin-$\frac{3}{2}$ Ru1-Ru2 chains are formed. The Ru1 Ru2 moments ordered disordered (paramagnetic), respectively, below 15 K. This result indicates appearance a ...