نتایج جستجو برای: rs80359352

تعداد نتایج: 4  

Journal: :iranian journal of public health 0
mojgan ataei-kachouei javad nadaf mohammad taghi akbari morteza atri jacek majewski yasser riazalhosseini

background: germ-line mutations of brca1 and brca2 genes are responsible for approximately 25-30% of dominantly inherited familial breast cancers; still a big part of genetic component is unknown. the aim of this study was to investigate genetic causes of familial breast cancer in a pedigree with recessive pattern of inheritance. methods: we applied exome sequencing as a useful approach in hete...

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ژورنال: :پژوهش های آسیب شناسی زیستی 0
mojgan ataei-kachouei department of medical genetics, faculty of medical sciences, tarbiat modares university, tehran, iran javad nadaf department of human genetics, mcgill university, montreal, canada mohammad taghi akbari department of medical genetics, faculty of medical sciences, tarbiat modares university, tehran, iran morteza atri cancer research institute, tehran university of medical sciences, tehran, iran jacek majewski mcgill university and genome quebec innovation center, montreal, canada yasser riazalhosseini mcgill university and genome quebec innovation center, montreal, canada masoud garshasbi

هدف: از زمان شناسایی دو ژن پرنفوذ brca1/2 با وراثت بارز در دهه 1990 تاکنون ژن‏های مختلفی شناسایی شده‏است که در مجموع حدود 25 درصد اساس ژنتیکی سرطان پستان ارثی را توضیح می‏دهد و حداقل 75 درصد آن همچنان ناشناخته باقی مانده است. هدف از انجام این مطالعه بررسی وجود یا عدم وجود الگوی وراثتی مغلوب در این بیماری هتروژن است که احتمال وجود آن توسط برخی از محققین مطرح شده است. مواد و روش‏ها: در این مطالعه...

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Journal: :modares journal of medical sciences: pathobiology 2014
mojgan ataei-kachouei javad nadaf mohammad taghi akbari morteza atri jacek majewski

objective: since the identification of the two highly penetrant dominantly inherited genes, brca1/2, in the 1990s, a number of other genes have been identified which account for approximately 25% of the genetic basis for hereditary breast cancer. at least 75% are unidentified. the goal of this study is to investigate the presence or absence of a recessive pattern of inheritance in this heteroge...

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2015
Mojgan ATAEI-KACHOUEI Javad NADAF Mohammad Taghi AKBARI Morteza ATRI Jacek MAJEWSKI Yasser RIAZALHOSSEINI Masoud GARSHASBI

BACKGROUND Germ-line mutations of BRCA1 and BRCA2 genes are responsible for approximately 25-30% of dominantly inherited familial breast cancers; still a big part of genetic component is unknown. The aim of this study was to investigate genetic causes of familial breast cancer in a pedigree with recessive pattern of inheritance. METHODS We applied exome sequencing as a useful approach in hete...

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