Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a syndrome that may be associated with many conditions, including malignancy. Three further cases of paraneoplastic RS3PE are described and the literature is reviewed. Paraneoplastic RS3PE is more frequently associated with solid tumors, in particular adenocarcinoma. The two clinical characteristics suggestive of paraneo...

the authors reported on a 35-yr-old woman presenting as remitting seronegative symmetrical synovitis with pitting edema (RS3PE) and, three months later, complaining of dry mouth. The autoantibody profile, Schirmer’s test and minor salivary gland biopsy were compatible with Sjogren’s syndrome (SS). Therefore, the authors diagnosed SS presenting as RS3PE, and affirmed that there has been no previ...

first Remmitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) syndrome which is characterized by symmetrical distal synovitis, tenosynovitis of the mucous sheaths of the flexor and extensor tendons of the hands, pitting edema of the hands and/or feet, seronegativity for the Rheumatoid Factor (RF) and benign prognosis, mainly affecting the elderly and the males, exquisite respon...

To cite: Nijsse B, Roks G. BMJ Case Reports Published online: 28 November 2012 doi:10.1136/bcr-2012007347 DESCRIPTION A 73-year-old man presented with paresthesias of the fingertips and weakness of the abductor pollicis brevis muscle and the opponens pollicis muscle of both hands. Carpal tunnel syndrome (CTS) was suspected and confirmed by electromyography. The presence of swelling and pitting ...

PATIENT Male, 67 FINAL DIAGNOSIS: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome Symptoms: Bilateral wrist swelling Medication: - Clinical Procedure: - Specialty: Rheumatology. OBJECTIVE Unusual or unexpected effect of treatment. BACKGROUND Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a rare clinical entity characteriz...

Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) is a rare rheumatologic condition frequently missed but easily treated. We describe a case of RS3PE and explore the literature surrounding this arthritis.

Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) is a rare clinical entity that is easily missed due to lack of knowledge. Syndrome is characterized by sudden onset of edema with swelling on the dorsum of the hands and by synovitis. Serological tests are negative and radiographic joint destruction does not occurs. Etiology of RS3PE syndrome is not known. It can occur as a...

RS3PE syndrome is an inflammatory disease which affects mainly males and responds rapidly to low-dose steroids. We describe the concurrence of RS3PE and lung malignancy in a 78-year-old woman. We recommend that an underlying malignancy should always be excluded in patients with RS3PE syndrome, even when general signs and symptoms such as weight loss, anorexia and fever are absent or uncertain.

An association between remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome and insulin or dipeptidyl peptidase-4 (DPP4) inhibitor therapy were previously reported. We encountered four cases of RS3PE syndrome with type 2 diabetes mellitus or impaired glucose tolerance (IGT) without insulin or DPP4 inhibitor medication.

Recently, it was reported that remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome could be complicated with solid tumors. In a retrospective, multicenter study between October, 2003 and September, 2010, we investigated the characteristics of patients with paraneoplastic RS3PE syndrome who fulfilled following criteria: (1) bilateral pitting edema of hands or feet o...