نتایج جستجو برای: rs12979860

تعداد نتایج: 367  

Journal: :The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 2016
Silvia Renata Cornelio Parolin Rizzo Diana Gazito Henrique Pott-Junior Flavia Roche Moreira Latini Adauto Castelo

The recent development of interferon-free regimens based on direct-acting antivirals for the treatment of chronic hepatitis C virus infection has benefited many but not all patients. Some patients still experience treatment failure, possibly attributed to unknown host and viral factors, such as IFNL3 gene polymorphism. The present study assessed the prevalence of rs12979860-CC, rs12979860-CT, a...

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ژورنال: مجله دانشگاه علوم پزشکی فسا 2015
Adim, nasim, Alborzi, Abdolvahab, Ghassabi, Farzaneh, Haj-Sheykholeslami, Arghavan, Hallaji, Mehrdad, Hashempour, Tayebeh, Merat, Shahin, Mirhoseini, Mahboobe, Moayedi, Javad, Musavi, Zahra, Pouladfar, Gholam Reza,

Background & Objective: Hepatitis C Virus (HCV) is one of the important risk factors for liver cirrhosis and hepatocellular carcinoma. Some of the host genetic factors such as interleukin 28B (IL-28B) may influence the response to the antiviral therapy. IL28B is a member of the interferon (IFN) family which causes an antiviral response. Previous studies indicated that rs12979860 polymorphisms o...

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Journal: :Clinical biochemistry 2014
Mark A Cervinski Soya S Sam Heather B Steinmetz Brendan Wood Gregory J Tsongalis

OBJECTIVES The favorable CC genotype at rs12979860 upstream of the interleukin (IL)-28B gene is correlated with a greater post-treatment sustained virologic response rate in chronic hepatitis C infected patients. We report on our validation of a clinical genotyping assay for rs12979860 polymorphisms in the IL28B locus. DESIGN AND METHODS The rs12979860 genotype was determined using a TaqMan® ...

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2013
Stéphanie Bibert Thierry Roger Thierry Calandra Murielle Bochud Andreas Cerny Nasser Semmo François H.T. Duong Tilman Gerlach Raffaele Malinverni Darius Moradpour Francesco Negro Beat Müllhaupt Pierre-Yves Bochud

Approximately 3% of the world population is chronically infected with the hepatitis C virus (HCV), with potential development of cirrhosis and hepatocellular carcinoma. Despite the availability of new antiviral agents, treatment remains suboptimal. Genome-wide association studies (GWAS) identified rs12979860, a polymorphism nearby IL28B, as an important predictor of HCV clearance. We report the...

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2015
Tadeusz Wojciech Łapiński Magdalena Rogalska-Płonska Anatol Panasiuk Oksana Kowalczuk Jacek Nikliński Robert Flisiak

AIM OF THE STUDY To determine distribution of rs12979860 genotypes, their correlations with viral load as well as inflammatory activity and stage of liver fibrosis in patients infected with HCV genotype 1. MATERIAL AND METHODS The study included 132 patients infected with HCV genotype 1b. Serum viral loads were obtained with the PCR method. Rs12979860 polymorphisms were determined by sequenci...

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2014
Luis M. Real Karin Neukam Rocío Herrero Josep M. Guardiola Thomas Reiberger Antonio Rivero-Juarez Juliana Salazar Mattias Mandorfer Dolores Merino Vicente Soriano Antonio Rivero Juan Macías Juan A. Pineda Antonio Caruz

OBJECTIVES The rs12979860 variant, linked to IL28B gene, predicts sustained viral response (SVR) to pegylated-interferon/ribavirin (pegIFN/RBV) therapy in Hepatitis C Virus genotype 1 or 4 (HCV-1/4)-infected patients. Recently, a functional variant, ss469415590, in linkage disequilibrium (LD) with rs12979860, has been discovered. Our objective was to assess the value of ss469415590 to predict S...

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2015
Giorgio Calisti Amanda Tavares Malcolm J Macartney Adele McCormick Wendy Labbett Michael Jacobs Geoffrey Dusheiko William M Rosenberg Tanzina Haque

Single nucleotide polymorphisms (SNPs) in the IL28B gene were shown to have limited utility in predicting response to telaprevir and boceprevir in treatment of chronic HCV infection in clinical trials. Data outside of the clinical trial setting are lacking. We assessed the value of single and combined IL28B SNPs rs12979860 and rs8099917 genotypes in predicting sustained virological response 12 ...

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Journal: :PloS one 2015
Steffen B Wiegand Benjamin Heidrich Simone Susser Magdalena Rogalska-Taranta Jörg Petersen Klaus H W Böker Natalia Grigorian Ralph Link Uwe Naumann Christine John Stefan Lueth Peter Malfertheiner Michael P Manns Heiner Wedemeyer Christoph Sarrazin Markus Cornberg

BACKGROUND SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generates IFNL4. In this study, we compared the role of IFNL4 variants with IFNL3-(rs12979860) and IFNL3-(rs8099917) on response to pegylated (PEG)-IFN an...

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Journal: :Journal of hepatology 2011
Christoph Sarrazin Simone Susser Alexandra Doehring Christian Markus Lange Tobias Müller Christina Schlecker Eva Herrmann Jörn Lötsch Thomas Berg

BACKGROUND & AIMS Genetic variation in the interleukin 28B (IL28B) gene has been associated with the response to interferon-alfa/ribavirin therapy in hepatitis C virus (HCV) genotype 1-infected patients. The importance of three IL28B single nucleotide polymorphisms (rs8099917, rs12980275 and rs12979860) for HCV genotype 2/3-infected patients is unknown. METHODS In patients with chronic hepati...

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Journal: :jundishapur journal of microbiology 0
fateme zare department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran hossein hadinedoushan department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran; department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran. tel: +98-3536285406, fax: +98-3536238561 mohsen akhondi meybodi depatment of gastrology, faculty of medicine, shahid sadoughi hospital, shahid sadoughi university of medical sciences, yazd, ir iran mahdi dehghanmanshadi department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran seyyed ali mirghanizade bafghi department of immunology, reproductive immunology research center, shahid sadoughi university of medical sciences, yazd, ir iran mahmood vakili department of community, faculty of medicine, shahid sadoughi university of medical sciences, yazd, ir iran

conclusions our findings indicate that patients with the homozygous cc genotype in the il28b gene had a significantly higher rate of response to treatment than those with the tt or ct genotypes. nor does the il28b rs12979860 polymorphism affect the viral load. results the genotype frequencies of rs12979860 polymorphism in group 1 were cc (28.9%), ct (37.8%) and tt (33.3%) and in group 2 were cc...

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