Background: Patients with multiple sclerosis (MS) report lower health-related quality of life (HRQoL) than other chronic disease populations. This study aims to identify risk factors relapsing or remitting (RRMS) and assess its impact on HRQoL in Lebanese MS patients. methods: A thre-month case-control was performed among 75 RRMS case patients recruited from two clinics Beirut 225 controls the ...

BACKGROUND Although most patients with relapsing-remitting multiple sclerosis (RRMS) will develop secondary progressive multiple sclerosis (SPMS), little is known about the burden of multiple sclerosis by disease subtype. This study describes the burden of disease in terms of demographics, disease severity, symptoms, health care resource and disease-modifying therapy (DMT) utilization, work and...

Multiple Sclerosis (MS) is a chronic, potentially debilitating disease that affects millions of patients worldwide. About 85% experience subtype characterised by relapses and remittance (RRMS). While many studies have investigated factors influencing patients’’ health-related quality life (HRQoL) in RRMS, none taken patients’ fear into account. In this study, we measured the self-reported HRQoL...

Abstract Background Cognitive dysfunction is common among patients with multiple sclerosis (MS); however, the determinants of cognitive are still unknown. This study aimed to investigate in a relatively large sample MS for rapid screening. Results Fifty-three (33.6%) had dysfunction. According Wechsler Memory Scale, relapsing-remitting (RRMS) and progressive (PMS) significantly lower scores tha...

OBJECTIVE Multiple sclerosis (MS) is a chronic, neurodegenerative autoimmune disorder affecting the central nervous system. Relapsing-remitting MS (RRMS) is the most common clinical form of MS and affects ∼85% of cases at onset. Highly active (HA) and rapidly evolving severe (RES) RRMS are 2 forms of RRMS amenable to disease-modifying therapies (DMT). This study explored the efficacy of fingoli...

OBJECTIVE To improve the characterization of asymptomatic subjects with brain magnetic resonance imaging (MRI) abnormalities highly suggestive of multiple sclerosis (MS), a condition named as "radiologically isolated syndrome" (RIS). METHODS Quantitative MRI metrics such as brain volumes and magnetization transfer (MT) were assessed in 19 subjects previously classified as RIS, 20 demographica...

OBJECTIVES Dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis has frequently been reported in multiple sclerosis (MS). So far, HPA axis function in MS has predominantly been studied under pharmacological stimulation which is associated with a series of methodological caveats. Knowledge of circadian cortisol patterns and cortisol awakening response (CAR) is still limited. METHODS A...

There is increasing evidence that neurofilament light chain (NF-L) can be considered as a biomarker for neuro-axonal damage. This polypeptide released into the cerebrospinal fluid (CSF) and blood, where it quantified. The concentration of NF-L elevated in patients with multiple sclerosis (MS) psychiatric disorders. We aimed to investigate levels CSF from treated MS relationship depression or an...

BACKGROUND Pathological destruction of blood-brain barrier (BBB) has been thought to be the initial key event in the process of developing multiple sclerosis (MS). The purpose of the present study was to clarify the possible molecular mechanisms responsible for the malfunction of BBB by sera from relapse-remitting MS (RRMS) and secondary progressive MS (SPMS) patients. METHODS We evaluated th...

Cortisol is a key regulator of the immune system, energy metabolism, and stress, yet its relevance to fatigue experienced by people with relapsing-remitting multiple sclerosis (RRMS) remains uncertain. We examined cortisol secretory activity in RRMS and its association with fatigue severity between-individuals and within-individuals (day-to-day) using a case-control ecological momentary assessm...