Background: Rotenone, a chemical compound produced naturally by leguminous plants, has conventionally been used as pesticide blocking the uptake of oxygen body cells. Our study aimed to investigate effect spirulina on oxidative damage, inflammation, and neurotoxicity in male mice treated rotenone. Methods: The experimental animals were divided into 5 groups. Group (I) served control that receiv...

background: both azadirachtin and rotenone, two botanical pesticides have shown inhibit the growth of cultured insect cells. the inhibitory effect of rotenone on cell growth is through disruption of electron transport chain, but exact mechanism of effect of azadirachtin on growth of cell is unknown. this study was carried out to compare the effect of these phytochemical on oxygen consumption by...

Objective(s): The effects of low dose amphetamine on oxidative stress and rotenone-induced neurotoxicity and liver injury were examined in vivo in a mice model of Parkinson’s disease. Materials and Methods: Male mice were treated with rotenone (1.5 mg/kg, every other day for two weeks, subcutaneously). Mice received either the vehicle or...

Rotenone is a widely used botanical insecticide, which can inhibit the mitochondrial respiratory chain of various insect cells, while mechanism its toxicity to cells needs further investigation. The purpose this study was understand level low (0.2 µg/mL) and high (20 concentrations rotenone in Spodoptera litura (SL-1) using trypan blue Coomassie brilliant staining assays. Our found that possess...

Abstract Background Cognitive decline occurs frequently in Parkinson’s disease (PD), which greatly decreases the quality of life patients. However, mechanisms remain to be investigated. Neuroinflammation mediated by overactivated microglia is a common pathological feature multiple neurological disorders, including PD. This study designed explore role cognitive deficits using rotenone-induced mo...

Chronic complex I inhibition caused by rotenone induces features of Parkinson's disease in rats, including selective nigrostriatal dopaminergic degeneration and Lewy bodies with alpha-synuclein-positive inclusions. To determine the mechanisms underlying rotenone-induced neuronal death, we used an in vitro model of human dopaminergic SH-SY5Y cells. In rotenone-induced cell death, rotenone induce...

Increasing evidence has suggested an important role for environmental factors such as exposure to pesticides in the pathogenesis of Parkinson's disease. In experimental animals the exposure to a common herbicide, rotenone, induces features of parkinsonism; mechanistically, rotenone-induced destruction of dopaminergic neurons has been attributed to its inhibition of the activity of neuronal mito...

Parkinson's disease is a chronic neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra. Rotenone, a pesticide, produces selective degeneration of dopaminergic neurons and motor dysfunction in rats. To determine the mechanisms underlying rotenone-induced neuronal death, we investigated whether intracellular dopamine plays a role in rotenone (0.1-0.4 mic...

We have tried the well-characterized respiratory inhibitor rotenone (1) and found it to be consistently tumorigenic in the albino rat. This finding, together with the mitochon dria! characteristics observed in the rotenone-induced tu mors, is reported here. Rotenone tumors represent a class of tumors produced by small amounts of a chemical com pound with a defined biochemical action. Furthermor...

Inhibition of mitochondrial respiratory chain complex I by rotenone had been found to induce cell death in a variety of cells. However, the mechanism is still elusive. Because reactive oxygen species (ROS) play an important role in apoptosis and inhibition of mitochondrial respiratory chain complex I by rotenone was thought to be able to elevate mitochondrial ROS production, we investigated the...