1. Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathological entity. Arch Pathol. 1969;87 (1):63-70. 2. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol. 1990;7(1):19-73. 3. Eisen RN, Buckley PJ, Rosai J. Immunophenotypic characterization of ...

Rosai-Dorfman disease is a rare benign histiocytic disease that infrequently presents in the spine. We report a case of Rosai-Dorfman disease isolated to the epidural thoracic spine in a 26-year-old male. To our knowledge, this is the 15th reported case of isolated spinal disease and only the fourth case of isolated thoracic epidural disease. Given its rarity as well as non-specific symptoms an...

Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology. The disease mainly affects lymph node tissue, although it is rarely confined to the skin. Here, we describe a 53-year-old woman with purely cutaneous Rosai-Dorfman disease. The patient presented with a large pigmented plaque on her left leg, and sparse erythematous papules on her face and arms. A complete ...

CRDD: cutaneous Rosai-Dorfman disease RDD: Rosai-Dorfman disease INTRODUCTION Rosai-Dorfman disease (RDD) is a benign nonLangerhans cell histiocytic disorder often involving the cervical lymph nodes. Extranodal disease was reported in 43% of patients with RDD in a review of the literature, with the skin reported to be the most common extranodal site. In the absence of lymph node involvement, RD...

1Department of Diabetes and Endocrine Internal Medicine, Chubu Rosai Hospital, Nagoya, Japan 2Center for Preventive Medicine, Chubu Rosai Hospital, Nagoya, Japan 3Department of Neurology, Chubu Rosai Hospital, Nagoya, Japan 4Department of Community Healthcare and Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan 5Department of Psychiatry, Nagoya University Graduate School...

ESR: erythrocyte sedimentation rate INTRODUCTION Rosai-Dorfman disease, also called sinus histiocytosis with massive lymphadenopathy, is a rare histiocytic condition of unknown etiology first described in 1969. Primary cutaneous manifestation without systemic involvement of Rosai-Dorfman disease is even more uncommon. Here we present a case of primary cutaneous manifestation of Rosai-Dorfman di...

INTRODUCTION Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman Disease, is a rare and benign source of lymphadenopathy first described in 1969, which mimics neoplastic processes. This disease commonly presents in children and young adults with supra-diaphragmatic lymphadenopathy or extranodal lesions consisting of tissue infiltrates composed of a polyclonal populatio...

Rosai-Dorfman disease is a rare, benign histiocytic proliferative disorder that usually affects the lymph nodes. Although extranodal involvement has been reported in diverse sites, manifestation in the cardiovascular system is extremely rare. Specifically, cardiac involvement in Rosai-Dorfman disease is an extraordinarily infrequent event. We describe a case of a 36-year-old female who presente...

Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy is a rare disorder that typically manifests as lymphadenopathy and systemic symptoms whose etiology remains poorly elucidated. The diagnosis is based on immunohistochemistry. Its treatment is poorly defined but the prognosis is usually favorable. Here we report a 14 year old boy who presented with massive bilateral cervi...

Rosai–Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis that was first described as sinus with massive lymphadenopathy by Rosai and Dorfman in 1969. While classical/nodal RDD typical, extranodal involvement seen up to 43% of all cases, 23% showing only lesions. Here, we present case disseminated RDD, where the initial symptoms were cutaneous manifestations.