objective: to determine the diagnostic value of blood cells surface markers in patients with acute appendicitis. methods: in this cross-sectional study, 71 patients who underwent appendectomy following a diagnosis of appendicitis were recruited during a one-year period. the patients were divided into two groups: patients with histopathologically confirmed acute appendicitis and subjects with no...

receiver operating characteristics (roc) curves have numerous applications for identifying a cut-off point in diagnostic tests. nonetheless, given that sometimes two cut-off points have to be specified simultaneously, the roc curve can be used to identify such points. the volume under the roc surface (vus) serves as a criterion for the accuracy of diagnostic tests. one of the unfortunate outcom...

Consider the ROC surface which is a generalization of the ROC curve for three−class diagnostic problems. In this work, we propose five criteria for the three−class ROC surface by extending the Youden index, the sum of sensitivity and specificity, the maximum vertical distance, the amended closest-to-(0,1) and the true rate. It may be concluded that these five criteria can be expressed as a func...

Three-way receiver operating characteristic (ROC) surface analysis involves the calculation of a volume under an ROC surface (VUS), which is a measure of discriminatory accuracy of 2 diagnostic tests for 3 diseases. Nonparametric methods for calculating VUS and its standard error have been developed. The author presents the code for roc3D, a Mathematica computer program for performing parametri...

The receiver operating characteristic (ROC) curve is an important tool to gauge the performance of classifiers. In certain situations of high-throughput data analysis, the data is heavily class-skewed, i.e. most features tested belong to the true negative class. In such cases, only a small portion of the ROC curve is relevant in practical terms, rendering the ROC curve and its area under the cu...

• This article reviews current state of the art of ROC surface analysis and illustrates its use through an application on a pancreatic cancer diagnostic marker. Receiver Operating Characteristic (ROC) surfaces have been studied in the literature essentially only during the last decade and are considered as a natural generalization of ROC curves in three-class diagnostic problems. This article p...