rivastigmine hydrogen tartrate (rht), one of the potential cholinesterase inhibitors, has received great attention as a new drug candidate for the treatment of alzheimer's disease. however, the bioavailability of rht from the conventional pharmaceutical forms is low because of the presence of the blood brain barrier. the main aim of the present study was to prepare positively charged eudragit r...

A highly efficient and convenient procedure for the enantioselective synthesis of (S)-Rivastigmine tartrate, a cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s disease, is accomplished by the treatment of versatile, readily accessible N-Ethyl-N-methyl carbamoyl chloride with 3-hydroxyacetophenone under ultrasonic irradiation in presence of nano-K2CO3 were repo...

Novel miniaturized polyvinyl chloride (PVC) membrane sensors in all-solid state graphite and platinum wire supports were developed, electrochemically evaluated and used for the assay of rivastigmine hydrogen tartrate drug (RIV). The RIV sensors are based on the formation of an ion-association complex between the drug cation and tetrakis(4-chlorophenyl)borate (TpClPB) anionic exchanger as electr...

AD is a neurodegenerative disorder charaterized by progressive decline of cognitive functions.The significant deficits in presynaptic cholinergic markers observed in brains of AD patients have led to the formulation of the cholinergic hyphotesis of AD. Current approaches to the treatment of cognitive and behavioral symptoms of AD emphasize the use of cholinesterase inhibitors. Rivastigmine (Exe...

The efficacy of a centrally active cholinesterase inhibitor, rivastigmine tartrate (ENA 713), in patients with advanced moderate Alzheimer's disease (AD) was evaluated in a 12-month placebo-controlled study. We aimed to investigate whether there was any evidence for the benefits of rivastigmine in patients with severe disease. These patients were compared with matched controls. In this study, 2...

1. Chez MG, Aimonovitch M, Buchanan T, Mrazek S, Tremb RJ. Treating autistic spectrum disorders in children: utility of the cholinesterase inhibitor rivastigmine tartrate. J Child Neurol. 2004;19:165-169. 2. Hertzmann M. Galantamine in the treatment of adult autism: a report of three clinical cases. Int J Psychiatry Med. 2003;33: 395-398. 3. Aman MG, Singh NN, Stewart AW, Field CL. The Aberrant...

Department of Pharmacy Sumandeep Vidyapeeth Vadodara( Gujarat)-391760 ABSTRACT A new simple, sensitive and selective UVspectrophotometric method was developed and dated for the estimation of Rivastigmine tartrate in bulk and in formulations. the method was applied for estimation of the drug present in the nanoparticles.RT was estimated at 264 nm in acetonitrile and in distill water.the linearit...