conclusions after paravertebral implantation of rifapentine polylactic acid sustained-release microspheres, the concentration of rifapentine in local vertebral bone tissues was maintained above the tb minimum inhibitory concentration for up to 60 days with no apparent accumulation of the drug in other tissues. methods this study is a basic animal experimental study that began on july 17, 2014 i...

BACKGROUND Rates of drug-resistant tuberculosis (TB) and TB associated with human immunodeficiency virus (HIV) infection have increased dramatically, intensifying challenges in TB control. New formulations of TB treatment drugs that control drug release and increase local drug concentrations will have a significant impact on mitigating the toxic side effects and increasing the clinical efficacy...

Rifapentine is a long-acting cyclopentyl-derivative of rifampin. This study was designed to investigate the mass balance and biotransformation of C-rifapentine in humans. Four healthy male volunteers received a single 600-mg oral dose of C-rifapentine in a hydroalcoholic solution. Whole blood, urine, and fecal samples were collected before and at frequent intervals after drug administration. Am...

The study was to develop and evaluate the rifapentine-loaded poly(lactic acid-co-glycolic acid) (PLGA) microspheres (RPMs) for the treatment of osteoarticular tuberculosis to avoid critical side effects caused by oral regimens of antibiotics or intravenous antibiotics. The RPMs were spherical with rough surfaces, and elevated amounts of rifapentine in the formulation markedly increased the part...

The use of biodegradable polymers in medicine and biomedical research is increasing. A key growth area has been the use of these materials in tissue engineering, especially for guided regeneration of bone and cartilage. Our interest has been in determining the mechanisms by which cellular attachment and growth occurs on these materials. In the current study, we examined human osteoblast cell ad...

Nifedipine is a hypertension drug must be consumed three times a day due to its low oral bioavailability. One way of developing a controlled drug delivery system is making nifedipine microcapsules by using environmentally friendly polymers of polylactic acid and polycaprolactone via the evaporation method using oil-in-water solvents. Polylactic acid and polycaprolactone can be said to be enviro...

objective(s): the current study reports the production and biocompatibility evaluation of a ternary nanocomposite consisting of ha, pla, and gelatin for biomedical application.materials and methods: hydroxyapatite nanopowder (ha: ca10(po4)6(oh)2) was produced by burning the bovine cortical bone within the temperature range of 350-450 oc followed by heating in an oven at 800. synthesis of the te...

This website provides an excellent overview of PLA as a polymer, its properties, and manufacture. This web article describes the production of lactic acid from biomass by microbial fermentation coupled to a poly-merization process to make PLA. The article is a bit dated and its industrial projections are now seen to be a bit over-optimistic. NatureWorks is the company that started large-scale p...