نتایج جستجو برای: rhoptry protein1 rop1 gene

تعداد نتایج: 1141967  

Journal: :archives of razi institute 2016
f. ghaffarifar a. dalimi z. eslamirad z. sharifi

toxoplasma gondii contain various immunogenic antigens. the most important toxoplasma antigens are somatic and excreted/secreted antigens. rhoptry proteins are known as excreted/secreted antigens. these antigens have been proposed as a vaccine candidate against toxoplasmosis. the main objective of the present work was cloning rhoptry protein1 (rop1) gene of toxoplasma gondii (rh) in a cloning v...

A. Dalimi, F. Ghaffarifar Z. Eslamirad Z. Sharifi

  Toxoplasma gondii contain various immunogenic antigens. The most important Toxoplasma antigens are somatic and excreted/secreted antigens. Rhoptry proteins are known as excreted/secreted antigens. These antigens have been proposed as a vaccine candidate against toxoplasmosis. The main objective of the present work was cloning rhoptry protein1 (ROP1) Gene of Toxoplasma gondii (RH) in a cloning...

Introduction:Toxoplasma gondii is a ubiquitous obligate intracellular parasite with a relatively broad host range infecting both mammals and birds. Toxoplasma proteins are strong antigens that can begin strong immune reactions, among which Rhoptry protein 1 (ROP1) can be named discharging from rhoptry cell-organ. ROP1 is regarded as a competitor for recombinant vaccines against toxoplasmosis. T...

2016
Parthasarathy Sonaimuthu Xiao T. Ching Mun Y. Fong Ramaswamy Kalyanasundaram Yee L. Lau

Toxoplasma gondii is the causative agent for toxoplasmosis. The rhoptry protein 1 (ROP1) is secreted by rhoptry, an apical secretory organelle of the parasite. ROP1 plays an important role in host cell invasion. In this study, the efficacy of ROP1 as a vaccine candidate against toxoplasmosis was evaluated through intramuscular or subcutaneous injection of BALB/c mice followed by immunological c...

Journal: :modares journal of medical sciences: pathobiology 2011
zahra eslami rad abdolhassein dalimi fatemeh ghaffarifar zohreh sharifi

objective: toxoplasmosis can lead to severe pathological effects in both infected humans and animals. the various dna vaccines against toxoplasma compose of single or cocktail antigens have been investigated but they have partial protective against disease. in this study, we used pcrop1 as a dna vaccine and aluminium phosphate and aluminium hydroxide to compare their efficacy as mineral adjuvan...

2013
Reyhaneh Mohabati Jalal Babaie Samira Amiri Mohammad Talebzadeh Pezhman Fard-Esfahani Mojtaba Darbouy Majid Golkar

BACKGROUND Toxoplasmosis is a worldwide-distributed infection which is mostly asymptomatic but can cause serious health problems in congenitally-infected newborns and immunecompromised individuals. Research is undergoing both to improve Toxoplasma serological tests, which play the main role in laboratory diagnosis of the infection, and develop an effective vaccine to prevent the infection. Some...

Journal: :Clinical and vaccine immunology : CVI 2009
Lucyna Holec-Gasior Józef Kur Elzbieta Hiszczyńska-Sawicka

A goal of the current study was to evaluate serological applications of Toxoplasma gondii GRA2 and rhoptry protein 1 (ROP1) antigens. Soluble recombinant GRA2 and ROP1 antigens as fusion proteins containing six histidyl residues at the N and C terminals were obtained using an Escherichia coli expression system. Purification by one-step metal affinity chromatography allowed recovery of milligram...

Journal: :The Korean journal of parasitology 2005
Aifen Lin Eun-Hee Shin Tae-Yun Kim Jae-Hwan Park Sang-Mee Guk Jong-Yil Chai

Toxoplasma gondii tachyzoites were isolated from an ocular patient in the Republic of Korea and maintained in the laboratory (designated KI-1). In the present study, its genotype was determined by analyzing dense granule antigen 6 (GRA6) gene and surface antigen 2 (SAG2) gene as typing markers. Digestion of the amplification products of GRA6 and of the 5o and 3o ends of SAG2, respectively, with...

Journal: :jundishapur journal of microbiology 0
zahra eslamirad department of parasitology, arak university of medical sciences, arak, ir iran; molecular and medicine research center, arak university of medical sciences, arak, ir iran; department of parasitology, arak university of medical sciences, arak, ir iran. tel: +98-8614173505, fax: +98-8614173521 fatemeh ghaffarifar depepartment of parasitology, faculty of medical sciences, tarbiat modares university, tehran, ir iran mana shojapour molecular and medicine research center, arak university of medical sciences, arak, ir iran behzad khansarinejad department of microbiology, arak university of medical sciences, arak, ir iran javid sadraei depepartment of parasitology, faculty of medical sciences, tarbiat modares university, tehran, ir iran

background toxoplasma gondii is an obligatory intracellular protozoan parasite, which infects human beings. since the current antigens used for diagnosis or vaccination are contaminated with non parasitic material in which the parasite is grown, it is tried to produce recombinant antigens to design vaccines against toxoplasmosis, or make diagnostic kits. choosing the type of antigen to produce ...

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