نتایج جستجو برای: rhomboid domain containing 1

تعداد نتایج: 3282829  

Journal: :Asian Pacific journal of cancer prevention : APJCP 2013
Xue-Ni Liu Zheng-Hao Tang Yi Zhang Qing-Chun Pan Xiao-Hua Chen Yong-Sheng Yu Guo-Qing Zang

Rhomboids were identified as the first intramembrane serine proteases about 10 years ago. Since then, the study of the rhomboid protease family has blossomed. Rhomboid domain containing 1 (RHBDD1), highly- expressed in human testis, contains a rhomboid domain with unknown function. In the present study, we tested the hypothesis that RHBDD1 was associated with proliferation and apoptosis in hepa...

Objective(s): A growing body of evidence indicates that rhomboid domain containing 1 (RHBDD1) plays an important role in a variety of physiological and pathological processes, including tumorigenesis. We aimed to determine the function of RHBDD1 in breast cancer cells. Materials and Methods: In this study, we used the Oncomine™ database to determine the expression patterns of RHBDD1 in normal a...

Journal: :Cell 2001
Sinisa Urban Jeffrey R. Lee Matthew Freeman

The polytopic membrane protein Rhomboid-1 promotes the cleavage of the membrane-anchored TGFalpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Until now, the mechanism of this key signaling regulator has been obscure, but our analysis suggests that Rhomboid-1 is a novel intramembrane serine protease that directly cleaves Spitz. In accordance with the putative R...

2015
Wei Song Wenjie Liu Hong Zhao Shangze Li Xin Guan Jianming Ying Yefan Zhang Fei Miao Mengmeng Zhang Xiaoxia Ren Xiaolu Li Fan Wu Yuechao Zhao Yuanyuan Tian Wenming Wu Jun Fu Junbo Liang Wei Wu Changzheng Liu Jia Yu Shudong Zong Shiying Miao Xiaodong Zhang Linfang Wang

Rhomboid proteins perform a wide range of important functions in a variety of organisms. Recent studies have revealed that rhomboid proteins are involved in human cancer progression; however, the underlying molecular mechanism remains largely unclear. Here we show that RHBDD1, a rhomboid intramembrane serine protease, is highly expressed and closely associated with survival in patients with col...

Journal: :Molecular medicine reports 2015
Junyi Han Junchao Bai Yao Yang Hua Yin Wei Gao Aiguo Lu Fei Liu Haiyan Ge Zhongmin Liu Jinyi Wang Lan Zhong

Rhomboid domain containing 1 (RHBDD1), is a member of the rhomboid protease family, which has a pivotal role in the progression of numerous severe malignancies. However, its role in colorectal carcinoma (CRC) remains to be elucidated. In the present study, RHBDD1 was shown to be widely expressed in CRC cell lines. Lentivirus-mediated RNA interference was employed to knockdown RHBDD1 expression ...

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