We report a patient with relapsed acute myelogenous leukemia after allogeneic stem cell transplantation who developed disseminated mucormycosis due to Rhizomucor pusillus/R. miehei involving lung, brain, and skin. After failing posaconazole and being intolerant to amphotericin, he was treated effectively with isavuconazole for over 6 months despite ongoing treatment for relapsed leukemia.

milk clotting enzyme (m ce) produced by: rhizomucor miehei was purified and characterized.the enzyme was purified 220.29-fold with specific activity about 14444.2 u/mg protein byultrafiltration, ammonium sulfate fractionation, sephacryl s-300 chromatography. the maximumenzyme activity was at 65°c.the milk clotting activity was decreased steadily as ph is increased and indicated maximumactivity ...

A twin inhibition is observed for the esterification reaction between ethanol and isovaleric acid using immobilized lipase from Rhizomucor miehei in hexane and in mixed solvent system. The observed bi-substrate inhibition pattern follows a Ping-Pong Bi-Bi mechanism with dead-end inhibition of enzyme by both the substrates. An increase in Km value for alcohol in mixed solvent (0.645 M) than in h...

Biochemical characterization of a novel L-asparaginase with low 1 glutaminase activity from Rhizomucor miehei and its application in 2 food safety and leukemia treatment 3 Linhua Huang, Yu Liu, Yan Sun, Qiaojuan Yan , Zhengqiang Jiang #, * 4 Bioresource Utilization Laboratory, College of Engineering, China Agricultural 5 University, Beijing 100083, China; School of Biological Science and Medica...

BACKGROUND Esterases with excellent merits suitable for commercial use in ester production field are still insufficient. The aim of this research is to advance our understanding by seeking for more unusual esterases and revealing their characterizations for ester synthesis. METHODOLOGY/PRINCIPAL FINDINGS A novel esterase-encoding gene from Rhizomucor miehei (RmEstA) was cloned and expressed i...

Enzymatic synthesis of sugar fatty acid esters were performed in an organic solvent using Immobilized Rhizomucor miehei (RMIM) lipase with sucrose and non-edible rice bran fatty acid as substrates. The maximum conversion of sucrose esters up to 78% obtained when sucrose and non-edible rice bran fatty acid were reacted in molar ratio of 1:8, using n-butanol as a solvent and 1% molecular sieves w...

Milk clotting enzyme (M CE) produced by: Rhizomucor miehei was purified and characterized.The enzyme was purified 220.29-fold with specific activity about 14444.2 U/mg protein byultrafiltration, ammonium sulfate fractionation, Sephacryl S-300 chromatography. The maximumenzyme activity was at 65°C.The milk clotting activity was decreased steadily as pH is increased and indicated maximumactivity ...

Enantioselectivity of enzyme catalysis is often rationalized via active site models. These models are constructed on the basis of comparing the enantiomeric excess of product observed in a series of reactions which are conducted with a range of homologous substrates, typically carrying various side chain substitutions. Surprisingly the practical application of these simple but informative 'pock...