purpose : to investigate and compare the causes of blindness in ocular behçet’s disease (bd) in men and women methods : in a retrospective, descriptive investigation from 1976 to 2008, 6,021 bd cases were registered in our bd unit of shariati hospital of tehran university of medical sciences (tums). at the last visit, 187 patients (124 men and 63 women) were blind (vision=1/10 or less) at least...

purpose: to report a case of acute retinal necrosis following herpetic encephalitis. case report: a 25-year-old male presented with pain and visual loss in his left eye. he had herpetic encephalitis 1 month prior to the visual symptoms. ophthalmologic examination and paraclinical evaluation disclosed acute retinal necrosis. conclusion: herpetic encephalitis may be a risk factor for acute retina...

purpose : to determine the association between retinal vascular diameter and its branching angles with diabetic retinopathy (dr) stages in diabetic patients methods : a descriptive analytic cross-sectional study was conducted in 62 diabetic patients (120 eyes) referred to farabi eye hospital between june 2008 and december 2009. digital fundus photography pictures were imported into photoshop so...

uncontrolled hypertension is well- known to give rise to systemic complications involving multiple central organs. artherosclerosis leads to damage of the retinal vessels wall, contributing to venous stasis, thrombosis and finally, occlusion. retinal vein occlusions compromise vision through development of ischaemic maculopathy, macular oedema, and rubeotic glaucoma. laser photocoagulation rema...

A 35-year-old black man developed abrupt visual loss in his left eye. Ophthalmic examination revealed a deeply pigmented mass obscuring the optic disc, hemorrhagic retinopathy, and signs of central retinal vascular obstruction. Fluorescein angiography disclosed sluggish filling of the retinal blood vessels; ultrasonography disclosed an acoustically solid mass in the optic nerve head. Cytopathol...

Diabetic retinopathy is characterized by blood-retinal barrier (BRB) breakdown and neurotoxicity. These pathologies have been associated with oxidative stress and proinflammatory cytokines, which may operate by activating their downstream target p38 MAP kinase. In the present study, the protective effects of a nonpsychotropic cannabinoid, cannabidiol (CBD), were examined in streptozotocin-induc...

PURPOSE to report a case of branch retinal artery occlusion in the acute phase, using optical coherence tomography to evaluate the morphologic changes. A 27 year-old man had a sudden superior scotoma in the right eye, with fundus examination compatible with inferior temporal branch retinal artery obstruction. The optical coherence tomography revealed increase in thickness and hyper-reflectivity...

Diabetic retinopathy is a leading cause of reduced visual acuity and acquired blindness. Available treatments are not completely effective. We analyzed the effect of environmental enrichment on retinal damage induced by experimental diabetes in adult Wistar rats. Diabetes was induced by an intraperitoneal injection of streptozotocin. Three days after vehicle or streptozotocin injection, animals...

Dysregulation of Wnt/β-catenin signaling contributes to the development of diabetic retinopathy by inducing retinal inflammation, vascular leakage, and neovascularization. Here, we evaluated the inhibitory effect of a monoclonal antibody (Mab) specific for the E1E2 domain of Wnt coreceptor low-density lipoprotein receptor-related protein 6, Mab2F1, on canonical Wnt signaling and its therapeutic...

A massive dose of 7.5 g of 4,4'-diamino, diphenyl sulphone (dapsone) taken as a suicide attempt in a patient on long-term therapy for tuberculoid leprosy resulted in permanent bilateral retinal necrosis, previously unreported side effect of this drug. The patient developed a severe haemolytic anaemia, methaemoglobinaemia, and acute renal failure requiring peritoneal dialysis. It is proposed tha...