Stem cells are undifferentiated cells that have the ability to convert to different types of cells and after dividing, they can produce their own cells or other cells. Axons of the retinal ganglion cells, from the optic nerve. These cells lose the ability to regenerate themselves before birth. Optic nerve degeneration can result from various causes including increased intraocular pressure, comp...

Glaucoma is the leading cause of preventable blindness worldwide. Despite tremendous advances in medical and surgical management of glaucoma in the recent years, the prevalence of glaucoma related blindness is anticipated to increase in the future decades because of the aging population. Stem cells have the potential to change the glaucoma management in several ways. There are several areas of ...

objective(s): the purpose of this study was to investigate the role of chloride channel protein 2 (clc-2) in glutamate-induced apoptosis in the retinal ganglion cell line (rgc-5). materials and methods: rgc-5 cells were treated with 1 mm glutamate for 24 hr. the expression of clc-2, bax, and bcl-2 was detected by western blot analysis. cell survival and apoptosis were measured by 3-(4,5-dimethy...

glaucoma is the leading cause of preventable blindness worldwide. despite tremendous advances in medical and surgical management of glaucoma in the recent years, the prevalence of glaucoma related blindness is anticipated to increase in the future decades because of the aging population. stem cells have the potential to change the glaucoma management in several ways. there are several areas of ...

Objective(s): The purpose of this study was to investigate the role of chloride channel protein 2 (ClC-2) in glutamate-induced apoptosis in the retinal ganglion cell line (RGC-5). Materials and Methods: RGC-5 cells were treated with 1 mM glutamate for 24 hr. The expression of ClC-2, Bax, and Bcl-2 was detected by western blot analysis. Cell survival and apoptosis were measured by 3-(4,5-dimeth...

glaucoma is a major cause of worldwide irreversible blindness. the central role of raised intraocular pressure (iop) is being questioned as many patients continue to demonstrate a clinically downhill course despite initial control of iop. the latest concept of recognizing glaucoma as a multifactorial, progressive, neurodegenerative disease of retinal ganglion cells (rgcss) associated with chara...

The transcription factor Brn3a has been reported to be a good marker for adult rat retinal ganglion cells in control and injured retinas. However, it is still unclear if Brn3a expression declines progressively by the injury itself or otherwise its expression is maintained in retinal ganglion cells that, though being injured, are still alive, as might occur when assessing neuroprotective therapi...

The fate of retinal ganglion cells after optic nerve injury has been thoroughly described in rat, but not in mice, despite the fact that this species is amply used as a model to study different experimental paradigms that affect retinal ganglion cell population. Here we have analyzed, quantitatively and topographically, the course of mice retinal ganglion cells loss induced by intraorbital nerv...

The different retinal cell types arise during vertebrate development from a common pool of progenitor cells. The mechanisms responsible for determining the fate of individual retinal cells are, as yet, poorly understood. Ganglion cells are one of the first cell types to be produced in the developing vertebrate retina and few ganglion cells are produced late in development. It is possible that, ...