the case is 43 years old woman referred to emergency department of our hospital with quadriplegia and severe respiratory insufficiency due to c5-c6 injury after falling. she discharged from icu after fixation of the lesion and successful weaning. we evaluated electrical activity of diaphragm signal (edi), respiratory drive (p100) during one month period. we detected increase in level of electri...

The pathophysiology of failure to wean from mechanical ventilation consists of depressed central respiratory drive, impaired respiratory mechanics, respiratory muscle weakness, increased load, impaired gas exchange, and compromised cardiovascular performance. Among patients with weaning failure, depressed central respiratory drive occurs in only a small portion (approximately 10%),1 whereas mos...

BACKGROUND The load imposed on ventilation by increased body mass contributes to the respiratory symptoms caused by obesity. A study was conducted to quantify ventilatory load and respiratory drive in obesity in both the upright and supine postures. METHODS Resting breathing when seated and supine was studied in 30 obese subjects (mean (SD) body mass index (BMI) 42.8 (8.6) kg/m(2)) and 30 nor...

case presentation in this report, ultrasound-guided sciatic nerve block was performed in a 25-year-old patient with tetanus to progress his respiratory drive which was decreased due to high dose sedative administration. this procedure accelerates the weaning process and extubation. introduction muscle rigidity and generalized spasm can cause severe pain in patients with tetanus. administration ...

The transmission of rhythmic drive to respiratory motoneurons in vitro is critically dependent on glutamate acting primarily on non-NMDA receptors. We determined whether both non-NMDA and NMDA receptors contribute to respiratory drive transmission at respiratory motoneurons in the intact organism, both in the state of anesthesia and in the same animals during natural behaviors. Twenty-seven rat...

The quantification of respiratory variability may provide insight into the integrative control of breathing. To test the hypothesis that sleep and/or increased chemical drive modifies respiratory variability, six male adult Sprague-Dawley rats were instrumented with diaphragm electromyographic (EMG) electrodes and exposed to 0, 2.5, and 5.0% CO2 with a balance of room air during wakefulness and...