نتایج جستجو برای: reprogramming

تعداد نتایج: 12767  

Journal: :iranian red crescent medical journal 0
maryam nazm bojnordi department of anatomical sciences, medical sciences faculty, tarbiat modares university, jalale-ale-ahmad highway, p.o. box 14115-175, ir iran +98-2182884503, [email protected] mansoureh movahedin department of anatomical sciences, medical sciences faculty, tarbiat modares university, jalale-ale-ahmad highway, p.o. box 14115-175, ir iran +98-2182884503, [email protected]; department of anatomical sciences, medical sciences faculty, tarbiat modares university, jalale-ale-ahmad highway, p.o. box 14115-175, ir iran +98-2182884503, [email protected] taki tiraihi department of anatomical sciences, medical sciences faculty, tarbiat modares university, jalale-ale-ahmad highway, p.o. box 14115-175, ir iran +98-2182884503, [email protected] mohamad javan department of physiology, medical sciences faculty, tarbiat modares university, ir iran

background new research proposes the pluripotency of spermatogonial cells obtained from testis. these spermatogonia-derived stem cells are called embryonic stem-like cells that express embryonic stem cell markers and differentiate to the three germ layers. objectives the aim of the present study was to generate embryonic stem-like cells from neonatal mouse testis. materials and methods the test...

a:4:{s:10:"Background";s:1707:"Early embryonic development in mammals begins in transcriptional silence with an oocyte-mediated transcriptional reprogramming of parental gametes occurs during a so called across-the-board process of “erase-and-rebuild”. In this process, the parental transcription programs are erased long before (maternal) or soon thereafter (paternal) fertilization to generate a...

Journal: :cell journal 0
kianoush dormiani hamid mir mohammad sadeghi hojjat sadeghi-aliabadi mahboobeh forouzanfar hossein baharvand kamran ghaedi

objective: induced pluripotent stem cells are generated from somatic cells by direct reprogramming. these reprogrammed pluripotent cells have different applications in biomedical fields such as regenerative medicine. although viral vectors are widely used for efficient reprogramming, they have limited applications in the clinic due to the risk for immunogenicity and insertional mutagenesis. acc...

Balbach SB Boiani M Esteves TC Pfeiffer MJ

Background: The mammalian oocyte has the unique feature of supporting fertilization and normal development while being able of reprogramming the nuclei of somatic cells towards pluripotency, and occasionally even totipotency. Whilst oocyte quality is known to decay with somatic ageing, it is not a given that different biological functions decay concurrently. In this study, we tested whether ooc...

Saman Esmaeilnejad, Sepideh Mansoori Majoofardi,

Multiple sclerosis (MS) is one of the most common neuroinflammatory disorders that causes disability in the young adults. In this disease immune-driven demyelination and following that inefficient remyelination occurs. Therapies for this disease are limited, especially those to enhance myelin repair. Cellular reprogramming using defined genetic factors is a way to produce remyelinating Oligoden...

Arauzo-Bravo Balbach ST Esteves TC Houghton F Jauch A Pfeiffer MJ Stehling M

Studies on cell fusion-mediated nuclear reprogramming have led to the breakthrough of the induced pluripotent stem (iPS) cell technology. While this technology has neared stem cells to applications more than any other method, the mechanistic bases of reprogramming remain largely unsolved. In this context, comparative studies of oocyte and cell fusion-mediated reprogramming hold the greatest pro...

s:1202:"It is a truly amazing time to developmental biology. During recent decades, three important breakthroughs have been developed: (i) isolation of stem cells from embryo, (ii) animal cloning by nuclear transfer (NT), and (iii) and induced pluripotent stem cells (iPS). Considering these three approaches of "Cellular Reprogramming", it seems that the required elements for cell therapy now ex...

Journal: :international journal of health studies 0
parvaneh sardarabadi 1 1. dept. of hematology, school of medical sciences, tarbiat modares university, tehran, iran. masoud soleimani 1* amir atashi 2 2. stem cell and tissue engineering research center, shahroud university of medical sciences, shahroud, iran. shahram pour beiranvand 1 mahshid akhavan rahnama 3 3. dept. of applied cell sciences, school of advanced technologies in medicine, shahid beheshti university of medical sciences, tehran, iran. azadeh anbarlou 3

background: induced pluripotent stem cells (ipscs) can be obtained from autologous cells for therapeutic purposes. so, far, many studies have been done to produce induced pluripotent cells by transferring specific pluripotency genes using different methods. in this study, pluripotency gene expression induced by external stresses was assessed in cord blood mononuclear cells. methods: in this exp...

Tian XC

Somatic cell nuclear transfer (SCNT or cloning) returns a differentiated cell to a totipotent status; a process termed nuclear reprogramming. Reproductive cloning has potential applications in both agriculture and biomedicine, but is limited by low efficiency. To understand the deficiencies of nuclear reprogramming, our research has focused on both candidate genes and global gene expression pat...

2016
Mizuki Kimura May Nakajima-Koyama Joonseong Lee Eisuke Nishida

Treatment with several Wnt/β-catenin signaling pathway regulators can change the cellular reprogramming efficiency; however, the dynamics and role of endogenous Wnt/β-catenin signaling in reprogramming remain largely unanswered. Here we identify the upregulation of WNT2 and subsequent β-catenin nuclear accumulation as key events in reprogramming. Transient nuclear accumulation of β-catenin occu...

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