menorrhagia is one of the most common gynecological problem and leading causes of poor quality of life and iron deficiency anemia in women of reproductive age. research in gynecological field relies heavily on repeated measure designs. repeated measure studies are helpful in understanding how factors of interest change over time. our goal is to apply statistical methods which are appropriate fo...

Repeated measures correlation (rmcorr) is a statistical technique for determining the common within-individual association for paired measures assessed on two or more occasions for multiple individuals. Simple regression/correlation is often applied to non-independent observations or aggregated data; this may produce biased, specious results due to violation of independence and/or differing pat...

Fisher (1943) claimed that the expected value of sample variance number species found in large samples, each n specimens taken from same population, is asymptotically ?log2. This at odds with ?logn obtained directly Ewens Sampling Formula (ESF), where ? specifies rate which new are found. To resolve this apparent contradiction, we assume frequency spectrum population determined by ESF and sampl...

BACKGROUND The primary analysis in a longitudinal randomized controlled trial is sometimes a comparison of arms at a single time point. While a two-sample t-test is often used, missing data are common in longitudinal studies and decreases power by reducing sample size. Mixed models for repeated measures (MMRM) can test treatment effects at specific time points, have been shown to give unbiased ...

Discriminant analysis (DA) encompasses procedures for classifying observations into groups (i.e., predictive discriminative analysis) and describing the relative importance of variables for distinguishing amongst groups (i.e., descriptive discriminative analysis). In recent years, a number of developments have occurred in DA procedures for the analysis of data from repeated measures designs. Sp...