نتایج جستجو برای: reovirus

تعداد نتایج: 1929  

Journal: :iranian journal of virology 0
a ataei-pirkooh department of virology, faculty of medicine, iran university of medical sciences, tehran, iran m shamsi-shahrabadi department of virology, faculty of medicine, iran university of medical sciences, tehran, iran hr monavari department of virology and antimicrobial resistance research center, iran university of medical sciences, tehran, iran a shafiei razi vaccine and serum institute, karaj, iran

background and aims: inhibition of viral growth in coinfected cells with two different viruses has been described. this phenomenon known as viral interference can occur in several virus host systems such as interference of enterovirus infection on poliovirus vaccine strains. in this study we superinfected reovirus infected hela cells with poliovirus to determine if poliovirus can replicate in s...

Journal: :Microbiological reviews 1981
W K Joklik

INTRODUCTION ................ ................................ 483 DISCOVERY OF REOVIRUSES .............................................. 483 STRUCTURE OF THE REOVIRUS PARTICLE .................. ............. 484 REOVIRUS GENOME ................................................ 484 PROTEINS OF REOVIRUS ................................................ 486 INFORMATION CONTENT OF THE 10 REOVIRUS G...

P.W.K Lee , S.A Gujar ,

Abstract :  Reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  The efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  Cells expressing ac...

2015
Yuki Katayama Yuichi Terasawa Masashi Tachibana Hiroyuki Mizuguchi Fuminori Sakurai

Oncolytic reovirus induces innate immune responses, which contribute to the antitumor activity of reovirus, following in vivo application. Reovirus-induced innate immune responses have been relatively well characterized in immune cells and mouse embryonic fibroblasts cells; however, the mechanisms and profiles of reovirus-induced innate immune responses in human tumor cells have not been well u...

Background and Aims: Oncolytic reoviruses can infect and kill malignant cells while sparing their normal counterparts. Reoviral infection can induce or activate autophagy, even though metformin can induce autophagy. Identifying and regulating the cellular pathways important for reovirus replication and oncolysis can improve targeted-biological therapies for cancer. Here, the autophagic process ...

Journal: :iranian journal of virology 0
s.a gujar department of microbiology and immunology, dalhousie university halifax, nova scotia, canada p.w.k lee department of microbiology and immunology, dalhousie university halifax, nova scotia, canada

abstract :  reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  the efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  cells expressing activated ras and t...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Wen Qing Yang Xueqing Lun Cheryl Ann Palmer M Elizabeth Wilcox Huong Muzik Zhong Qiao Shi Richard Dyck Matt Coffey Brad Thompson Mark Hamilton Sandra G Nishikawa Penny M A Brasher Kevin Fonseca David George N Berry Rewcastle Randal N Johnston Doug Stewart Patrick W K Lee Donna L Senger Peter A Forsyth

PURPOSE Human reovirus type 3 has been proposed to kill cancer cells with an activated Ras signaling pathway. The purpose of this study was to investigate the efficacy of reovirus in immunocompetent glioma animal models and safety/toxicity in immunocompetent animals, including nonhuman primates. EXPERIMENTAL DESIGN Racine glioma cells 9L and RG2 were implanted s.c. or intracranially in Fisher...

H. Hoseini M. Mayahi, R. A. Jafari S. Khademian Z. Boroomand

Background: Avian reovirus (ARV) has a global distribution in nature and most clinical signs are found in broiler type chickens. Aims: This study was conducted to detect and identify reovirus infections from vaccinated breeder chickens and their progenies. Methods: A total of 20 tissue and blood samples were collected from vaccinated broiler br...

2013
Da Pan Paola Marcato Dae-Gyun Ahn Shashi Gujar Lu-Zhe Pan Maya Shmulevitz Patrick W. K. Lee

Mammalian reovirus is a benign virus that possesses the natural ability to preferentially infect and kill cancer cells (reovirus oncolysis). Reovirus exploits aberrant Ras signalling in many human cancers to promote its own replication and spread. In vitro and in vivo studies using reovirus either singly or in combination with anti-cancer drugs have shown very encouraging results. Presently, a ...

2013
Chung Chew Hwang Saori Umeki Masahito Kubo Toshiharu Hayashi Hiroshi Shimoda Masami Mochizuki Ken Maeda Kenji Baba Hiroko Hiraoka Matt Coffey Masaru Okuda Takuya Mizuno

The usage of reovirus has reached phase II and III clinical trials in human cancers. However, this is the first study to report the oncolytic effects of reovirus in veterinary oncology, focusing on canine mast cell tumor (MCT), the most common cutaneous tumor in dogs. As human and canine cancers share many similarities, we hypothesized that the oncolytic effects of reovirus can be exploited in ...

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