background. the major side effect of cisplatin, used in some tumours, is nephrotoxicity. reactive oxygen species and oxidative damage are the most important factors in cisplatin-induced acute renal failure. the main purpose of this study is to investigate the protective effects of crocin against cisplatin-induced acute renal failure and oxidative stress in rat. methods. in this study, animals w...

conclusions good knowledges for renal function remain a hallmark of daily practice of the anesthesiologist, considering renal function as an important determinant factor in anesthesia practice. context pre-existing renal dysfunction presents specific features that anesthesiologists must deal with. anesthesia and renal function are connected and can interfere with each other. induced hypotension...

We showed previously that activation of A(1) adenosine receptors (AR) protects against renal ischemia-reperfusion (IR) injury in rats and mice. In the heart, transient A(1)AR activation produces biphasic protective effects: acute protection wanes after several hours but protective effects return 24-72 h later (second window of protection). In this study, we determined whether A(1)AR activation ...

BACKGROUND Acute renal failure from ischemia significantly contributes to morbidity and mortality in clinical settings, and strategies to improve renal resistance to ischemia are urgently needed. Here, we identified a novel pathway of renal protection from ischemia using ischemic preconditioning (IP). METHODS AND FINDINGS For this purpose, we utilized a recently developed model of renal ische...

introduction: during hemorrhagic shock (hs), the kidneys are one of the primary target organs involved. oxidative stress is shown to be enhanced in different models of acute kidney injury (aki). remote ischemic preconditioning (rpc) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. in this study, we investigated the effects of brief hind l...

Introduction: During hemorrhagic shock (HS), the kidneys are one of the primary target organs involved. Oxidative stress is shown to be enhanced in different models of acute kidney injury (AKI). Remote ischemic preconditioning (RPC) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. In this study, we investigated the effects of brief hind l...