Meldrum, Kirstan K., Daniel R. Meldrum, Xianzhong Meng, Lihua Ao, and Alden H. Harken. TNF-dependent bilateral renal injury is induced by unilateral renal ischemiareperfusion. Am J Physiol Heart Circ Physiol 282: H540–H546, 2002; 10.1152/ajpheart.00072.2001.—While tumor necrosis factor (TNF)is an important mediator of renal ischemiareperfusion (I/R) injury, its role in contralateral renal injur...

Glycogen synthase kinase-3β (GSK3β) is a serine/threonine protein kinase that plays an important role in renal tubular injury and regeneration in acute kidney injury. However, its role in the development of renal fibrosis, often a long-term consequence of acute kidney injury, is unknown. Using amousemodel of renal fibrosis induced by ischemia-reperfusion injury, we demonstrate increased GSK3β e...

3. Li Volti G, Sorrenti V, Murabito P et al. Pharmacological induction of heme oxygenase-1 inhibits iNOS and oxidative stress in renal ischemiareperfusion injury. Transplant Proc 2007; 39: 2986–2991 4. Datta PK, Koukouritaki SB, Hopp KA et al. Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis. J Am Soc Nephrol 1999; 10: 2540–2...

This study aimed to investigate tourniquet-induced compartment syndrome of the limb, consequential development multiple organ dysfunction syndrome, and its counteraction with pentadecapeptide BPC 157 therapy.

Kinsey GR, McHowat J, Beckett CS, Schnellmann RG. Identification of calcium-independent phospholipase A2 in mitochondria and its role in mitochondrial oxidative stress. Am J Physiol Renal Physiol 292: F853–F860, 2007. First published October 17, 2006; doi:10.1152/ajprenal.00318.2006.—Oxidant-induced lipid peroxidation and cell death mediate pathologies associated with ischemiareperfusion and in...

Ischemia-reperfusion injury is a serious problem which can occur during lung transplantation. Preservation of pulmonary function by reducing ischemia-reperfusion injury is essential for successful lung transplantation. Although the mechanisms responsible for ischemia-reperfusion lung injury are not clear yet, it is commonly accepted that ischemic time, storage conditions and additive usage of s...

Xu Z, Prathapasinghe G, Wu N, Hwang SY, Siow YL, O K. Ischemia-reperfusion reduces cystathionine-synthase-mediated hydrogen sulfide generation in the kidney. Am J Physiol Renal Physiol 297: F27–F35, 2009. First published May 13, 2009; doi:10.1152/ajprenal.00096.2009.—Cystathionine-synthase (CBS) catalyzes the rate-limiting step in the transsulfuration pathway for the metabolism of homocysteine ...