نتایج جستجو برای: redox homeostasis

تعداد نتایج: 112752  

2016
Fulvio Ursini Matilde Maiorino Henry Jay Forman

The notion that electrophiles serve as messengers in cell signaling is now widely accepted. Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as components of maintenance of a normal physiological steady state. The first is that redox signaling requires sudden switching on of oxidant production and bypassing of antioxidant mechanisms rather than a continuous...

2017
Chunhua Zhao Qiuwei Zhao Yin Li Yanping Zhang

The biosynthetic pathways of most alcohols are linked to intracellular redox homeostasis, which is crucial for life. This crucial balance is primarily controlled by the generation of reducing equivalents, as well as the (reduction)-oxidation metabolic cycle and the thiol redox homeostasis system. As a main oxidation pathway of reducing equivalents, the biosynthesis of most alcohols includes red...

Journal: :The Journal of experimental biology 2012
Michalis G Nikolaidis Antonios Kyparos Chrysoula Spanou Vassilis Paschalis Anastasios A Theodorou Ioannis S Vrabas

The central aim of this review is to address the highly multidisciplinary topic of redox biology as related to exercise using an integrative and comparative approach rather than focusing on blood, skeletal muscle or humans. An attempt is also made to re-define 'oxidative stress' as well as to introduce the term 'alterations in redox homeostasis' to describe changes in redox homeostasis indicati...

2012
Anita Ayer Sina Fellermeier Christopher Fife Simone S. Li Gertien Smits Andreas J. Meyer Ian W. Dawes Gabriel G. Perrone

Maintenance of an optimal redox environment is critical for appropriate functioning of cellular processes and cell survival. Despite the importance of maintaining redox homeostasis, it is not clear how the optimal redox potential is sensed and set, and the processes that impact redox on a cellular/organellar level are poorly understood. The genetic bases of cellular redox homeostasis were inves...

2015
Xiaofeng Wang Shuo Li Yu Liu Changle Ma

Peroxisomes are ubiquitous organelles present in nearly all eukaryotic cells. Conserved functions of peroxisomes encompass beta-oxidation of fatty acids and scavenging of reactive oxygen species generated from diverse peroxisomal metabolic pathways. Peroxisome content, number, and size can change quickly in response to environmental and/or developmental cues. To achieve efficient peroxisome hom...

Journal: :Oxidative Medicine and Cellular Longevity 2012

Journal: :Cell reports 2016
Vikram Saini Bridgette M Cumming Loni Guidry Dirk A Lamprecht John H Adamson Vineel P Reddy Krishna C Chinta James H Mazorodze Joel N Glasgow Melissa Richard-Greenblatt Anaximandro Gomez-Velasco Horacio Bach Yossef Av-Gay Hyungjin Eoh Kyu Rhee Adrie J C Steyn

The mechanisms by which Mycobacterium tuberculosis (Mtb) maintains metabolic equilibrium to survive during infection and upon exposure to antimycobacterial drugs are poorly characterized. Ergothioneine (EGT) and mycothiol (MSH) are the major redox buffers present in Mtb, but the contribution of EGT to Mtb redox homeostasis and virulence remains unknown. We report that Mtb WhiB3, a 4Fe-4S redox ...

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