objective: because of the host immunological system response against the minor blood groups of donor, transfusion in some cases, especially for patients require repeated transfusions (such as people with thalassemia), can be considered as a significant problem.  a proposed way is coating the surface antigens on red blood cells (rbcs) by covalent binding of methoxy polyethylene glycol (mpeg). th...

In healthcare systems, one of the important actions is related to perishable products such as red blood cells (RBCs) units that its consumption management in different periods can contribute greatly to the optimality of the system. In this paper, main goal is to enhance the ability of medical community to organize the RBCs units’ consumption in way to deliver the unit order timely with a focus ...

Objective(s): Evaluation of nanomaterials interaction with blood ingredients is a part of preclinical risk assessment of newly-synthesized materials, especially for nano-sized pharmaceuticals which are intravenously administrated. The red blood cells (RBCs) are susceptible to oxidative stress damage. This study was designed to evaluate induced oxidative hematotoxic effect of na...

Methoxy poly(ethylene glycol) (mPEG) with molecular mass of 5 kDa activated with succinimidyl carbonate and cyanuric chloride, separately was covalently attached to human red blood cells (RBCs). Inhibition of agglutination by blood-type specific antisera (anti-D) was employed to evaluate the effect of the polymer coating. The remaining single cells after incubation with anti-D sera were cou...

methoxy poly(ethylene glycol) (mpeg) with molecular mass of 5 kda activated with succinimidyl carbonate and cyanuric chloride, separately was covalently attached to human red blood cells (rbcs). inhibition of agglutination by blood-type specific antisera (anti-d) was employed to evaluate the effect of the polymer coating. the remaining single cells after incubation with anti-d sera were counted...

The remarkable deformability of red blood cells (RBCs) depends on the viscoelasticity plasma membrane and cell contents surface area to volume (SA:V) ratio; however, it remains unclear which these factors is key determinant for passage through small capillaries. We used a microfluidic device examine traversal normal, stiffened, swollen, parasitised immature RBCs1. show that dramatic stiffening ...

Background and Aims: Thyroid hormones have an important role in metabolism and regulation of the red blood cells (RBCs). Thyroid dysfunction induces various effects on blood cells such as anemia through reducing the oxygen metabolism. For the first time, we aimed to determine the effects of severity activation of hypothyroidism on RBCs indices in patients with hypothyroidism. Materials and Met...

BACKGROUND AND OBJECTIVES Athletes may illegally enhance endurance performance by transfusing homologous red blood cells (RBCs) and thereby increasing the oxygen carrying capacity of their blood. Detecting this dangerous practice is difficult by currently used methods. The aim of this work was to develop tests capable of detecting a mixed red cell population by flow cytometry, utilizing the lik...

Human red blood cells sensitized with concanavalin A became bound to homologous peripheral blood monocytes. Binding occured at a concentration of 10(5) molecules of tetrameric Con A per red blood cell (RBC) and increased with additional Con A. RBC binding began within 5 min and was maximal at 90 min. Phagocytosis of sensitized RBCs was minimal. RBC attachment was prevented by 0.01 M alpha-methy...

The separation of red blood cells (RBCs) from plasma and the analysis individual RBCs are great importance, as they provide valuable information regarding health their donor. Recent developments in microfluidics microfabrication have contributed to fabrication microsystems with complex features promote RBCs. In this work, capacity a multi-step crossflow microfluidic device was evaluated by usin...