Recurrent implantation failure (RIF) has many definitions, but usually authors consider RIF, the failure to achieve a pregnancy fallowing 2-6 IVF cycles in which more than 10 high grade embryos were transferred to the uterus. There are a lot of causes for RIF but two main causes of that are related to embryo and endometrium. Chromosomal abnormalities, zona hardening and problems in culture medi...

the success rate of reproductive treatment methods depends on many different factors. the most important and discussed ones in the literature are maternal age, the causes of infertility, the ovarian response to stimulation, the influence of the male factor and sperm quality, embryo quality and the various uterine pathologies. some couples fail repeatedly after transferring good quality embryos ...

Background: RIF is the most common cause of unsuccessful pregnancy after IVF. Among the various causes of RIF, the role of maternal genetic factors is of great significance. PAI-1 polymorphism is one of the notable polymorphisms in this field. In this study, the relationship between this polymorphism and the recurrent spontaneous abortions and infertility in different populations has been inves...

Abstract Recurrent implantation failure (RIF) is an imprecisely defined disorder lacking a robust scientific basis. The incomplete understanding of RIF provides significant diagnostic and therapeutic challenges, better the underlying issues necessary to improve outcomes. We propose novel concept termed ‘Theoretical Cumulative Implantation Rate’, calculation which based on objective data, define...

background: implantation failure of blastocyst is one of the main reasons of failure to become pregnancy following use of assisted reproductive techniques. hla-g, one of the non-classic hla subtypes, seems to have a vital role in neutralizing of mother immune system. according to importance of ins/del polymorphism of hla-g in regulation of hla-g expression, it seems that this polymorphism has a...

AIM To study the transcriptome profiles in the blood of recurrent implantation failure (RIF), recurrent miscarriage (RM) and fertile women during the window of implantation, and further analysis the correlation of transcriptome profiles between blood and endometrium. METHODS This is an observational prospective study. In total 9 subjects were recruited, 3 RIF, 3 RM, and 3 controls. Paired sam...

The primary limiting factor for effective IVF treatment is successful embryo implantation. Recurrent implantation failure (RIF) is a condition whereby couples fail to achieve pregnancy despite consecutive embryo transfers. Here we describe the collection of gene expression profiles from mid-luteal phase endometrial biopsies (n = 115) from women experiencing RIF and healthy controls. Using a sig...

BACKGROUND Recurrent implantation failure (RIF) is the absence of implantation after three consecutive In Vitro Fertilization (IVF) cycles with transferring at least four good quality embryos in a minimum of three fresh or frozen cycles in a woman under 40 years. The definition and management of RIF is under constant scrutiny. OBJECTIVE To investigate the effects of Granulocyte colony stimula...

Background: Repeated Implantation Failure (RIF) is one of the most intricate obstacles in assisted reproduction. The cytokine and chemokine composition of uterine cavity seem to play important roles in the implantation process. Objective: To compare the cytokine profile in the endometrium of normal fertile women and those with repeated implantation failure. Methods: After enzymatic digestion of...

background: repeated implantation failure (rif) is one of the most intricate obstacles in assisted reproduction. the cytokine and chemokine composition of uterine cavity seem to play important roles in the implantation process. objective: to compare the cytokine profile in the endometrium of normal fertile women and those with repeated implantation failure. methods: after enzymatic digestion of...