the postgastrectomy recurrence rate is as high as 30-65%, with 5-year overall survival rates of <20%. local recurrence is very common which occurs in 38-45% of cases. the most common sites of locoregional recurrence are the gastric remnant at the anastomosis, the gastric bed, and the regional nodes. the recurrence may occur as early and late events after gastrectomy. most recurrences are early,...

BACKGROUND There is a great need for effective outpatient chemotherapy for advanced gastric cancer in patients with good performance status. The present pilot study evaluated the use of combination chemotherapy with S-1 and fractional CDDP for unresectable-recurrent gastric cancer in an outpatient setting. PATIENTS AND METHODS A total of 41 patients with unresectable or recurrent gastric canc...

background : gastric cancer is a common and lethal disease throughout the world. in iran with 7300 new cases annually, it is the first cause of cancer related death in both sexes. regarding the high incidence (10.5/100000 individuals) of gastric can­cer and priority of prevalence index in cancer management, in this study we tried to determine 1, 2-3 and 4-5 year point preva­lence of the disease...

BACKGROUND Several large studies have reported an extremely low incidence of MET gene amplification (GA) in patients with radically resected gastric cancer. This study was conducted to evaluate the prevalence and prognostic role of MET in patients with recurrent=metastatic gastric cancer who received chemotherapy. METHODS MET GA and protein expression of recurrent=metastatic gastric cancer sa...

Background: Cytotoxin-associated gene A (CagA)-positive strains of Helicobacter pylori are associated with gastroduodenal diseases. Evidences have suggested that the type of H pylori CagA EPIYA motifs may be associated with specific disorders (i.e., gastritis, peptic ulcer, or gastric cancer).&nbsp; We investigated the prevalence of different EPIYA motifs (A, B, C, or D) in H. pylori strains is...

S-1 plus cisplatin is the standard chemotherapy for recurrent gastric cancer. While depression and delirium are frequent in cancer patients, hypomania during chemotherapy is rare. We describe a rare case of hypomania during S-1 plus cisplatin treatment for recurrent gastric cancer. A 66-year-old woman, with no previous psychiatric disorder, received S-1 plus cisplatin for recurrent gastric canc...

The identification of genes associated with recurrent drug resistance in gastric cancer and the elucidation of the underlying molecular mechanisms associated with recurrent drug resistance in gastric cancer are important for the effective treatment and prognosis of this cancer. Variations in the expression level of the ATP-binding cassette subfamily C member 4 (ABCC4) gene are correlated with t...

c-Myc overexpression has been implicated in several malignancies including gastric cancer. Here, we report that acidified bile acids enhance tumor progression and telomerase activity in gastric cancer via c-Myc activation both in vivo and in vitro. c-Myc mRNA and protein levels were assessed in ten primary and five local recurrent gastric cancer samples by quantitative real-time polymerase chai...

introduction and aims: both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations. recent cancer registry data have shown very different rates of esophageal cancer (ec) and gastric cancer (gc) in four provinces of iran, namely ardabil, mazandaran, golestan, and kerman. the aim of this st...