flecainide has been known to cause torsades de pointes (tdp) in patients with structural heart disease and its mechanism has been attributed to use-dependency. we present a patient with flecainide-induced tdp in the absence of any other precipitating factors.this case highlights potential reverse use dependence associated with flecainide resulting in tdp.

This receptor family comprises a group of receptors for the calcitonin/CGRP peptides. The calcitonin (CT), amylin (AMY), gene-related peptide (CGRP) and adrenomedullin (AM) (nomenclature as agreed by NC-IUPHAR Subcommittee on CGRP, AM, AMY, CT [131, 74, 71]) are generated genes CALCR (which codes receptor, CTR) CALCRL receptor-like CLR, previously known CRLR). Their function pharmacology altere...

Objective(s): -methyl-D-aspartate NMDA receptor (NMDAR) and aquaporin 4 (AQP4) are involved in the molecular cascade of edema after traumatic brain injury (TBI) and are potential targets of studies in pharmacology and medicine. However, their association and interactions are still unknown.Materials and Methods: We established a rat TBI model in this study. The cellular distribution patterns of ...

Receptor heteromerization has the potential to alter every facet of receptor functioning, leading to new pharmacological profiles with increased signaling diversity and regulation from that of the monomeric receptor, or indeed receptor homomer. An understanding of the molecular consequences of receptor heteromerization will provide new insights into the physiology and pathology mediated by rece...

Objective: To analyze the potential mechanism of Xinyi San in treating rhinitis through network pharmacology. Methods: In database Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical composition and targets were got, target genes extracted from GeneCards databases. Then we constructed protein-protein interactions (PPI) genes, then analyzed Key GO analysis KEGG analysis. Results:...

This chapter will review the basic pharmacology of endocannabinoid receptors. As the best-described cannabinoid receptors are G-protein-coupled receptors (GPCRs), those will be the focus of this chapter. We will start with a basic review of GPCR signaling, as these concepts are critical to understanding the function of cannabinoid receptors. Next, several features of cannabinoid receptor signal...