We report a new clinically relevant model of neonatal hypoxic-ischemic injury in a 10-day-old rat pup. Bilateral carotid artery occlusion and 8% hypoxia (1 to 15 mins, BCAO-H) was induced with varying degrees of injury (mild, moderate, severe), which was quantified using magnetic resonance imaging including diffusion-weighted and T2-weighted imaging at 24 h and 21/28 days. We developed a magnet...

Many antipsychotic drugs disrupt active components of maternal behavior such as pup approach, pup retrieval and nest building at clinically relevant doses in postpartum female rats. However, the neurochemical mechanisms underlying such a disruptive effect remain to be determined. This study examined the neurochemical mechanisms that mediate the disruptive effects of haloperidol (a typical antip...

background and aim: omega 3 of essential fatty acids, especially in fish oil form plays an important role in structural, functional, and biological aspects in body. omega 3 deficiency can have devastating effects on the nervous system and auditory. this study aimed to evaluate auditory threshold in n-3 fatty acid-deficient rat pups following supplementation of fish oil consumption during the suc...

Biorobotics research typically focuses on simulating specific aspects of animal biomechanics, sensory systems, and computational abilities. We have developed a novel methodology for integrating the study of biorobotics and animal behavior. We describe several metrics for characterizing and comparing rat pup and robot behavior without presupposing behavioral goal states. In the rat pup and robot...

The present study investigated hormonal mediation of maternal behavior and accumbal dopamine (DA) responses to pup-stimuli, as measured in microdialysis samples collected from the nucleus accumbens shell of female rats in non-homecage environment. In Experiment 1, samples were collected before and after continuous homecage pup experience from either intact postpartum or cycling females. In Expe...

Following repeated exposure to foster pups, virgin female rats acquire and eventually express a full spectrum of maternal caretaking behaviors directed toward pups. Though these behaviors are vigorous, these females are reportedly less motivated to seek out and interact with pups (i.e. maternally motivated) than parturient females during early postpartum. The present study systematically assess...

Impaired onset of maternal behavior in first generation rat dams was previously correlated with rearing by cocaine-treated dams and prenatal cocaine exposure. Pup-induced maternal behavior in non-lactating rats has not been examined with regard to cocaine exposure and rearing conditions. First generation male and female juveniles and young adult males reared by cocaine-treated or control dams a...

A previous study showed that hippocampal BDNF mRNA decreased in 17 day old (D17) rats, relative to agematched naïve rats, at day 1, 3, 7 and 14 after sham surgery in a traumatic brain injury model. The anesthetic isoflurane activates GABA and inhibits NMDA receptor currents, both of which are known to decrease Brain-Derived Neurotrophic Factor (BDNF) mRNA in rat hippocampi. Hippocampal BDNF is ...

Body heat loss was attenuated and oxygen consumption was reduced by huddling in litters of developing rats. Rat pups derive physiological benefits from huddling similar to those enjoyed by adult mammals; these findings contrast with previous characterization of the altricial rat as poikilothermic. Huddling insulates by lessening the explosed body surface area of the participants, thus retarding...