نتایج جستجو برای: rat model of alzheimers disease

تعداد نتایج: 21552439  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه بیرجند - دانشکده علوم 1391

in this thesis, we consider a mathematical model of cancer with completely unknown parameters. we study the stability of critical points which are biologically admissible. then we consider a control on the system and introduce situations at which solutions are attracted to critical points and so the cancer disease has auto healing. the lyapunov stability method is used for estimating the un...

Journal: :acta medica iranica 0
fatemeh alipour shafa neuroscience research center, tehran, iran. and department of animal physiology, faculty of biological sciences, tehran university of medical sciences, tehran, iran. shahrbanoo oryan department of animal physiology, faculty of biological sciences, tehran university of medical sciences, tehran, iran. mohammad sharifzadeh department of pharmacology and toxicology, school of pharmacy, tehran university of medical sciences, tehran iran. fariba karimzadeh shafa neuroscience research center, tehran, iran. and department of neuroscience,school of advanced medical technology, tehran university of medical sciences, tehran, iran. laya kafami shafa neuroscience research center, tehran, iran. and department of pathobiology, school of medicine, alborz university of medical sciences, alborz, iran. hamid irannejad department of medicinal chemistry, school of pharmacy, mazandaran university of medical sciences, mazandaran, iran.

alzheimer's disease (ad) is the most prevalent neurodegenerative disorder. it is characterized by formation of amyloid plaques and neurofibrillary tangles in the brain, degeneration of the cholinergic neurons and neural cell death. this study was aimed to investigate the effect of a triazine derivative, c16h12cl2n3s, on learning in an alzheimer's rat model. animals were divided into seven group...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علامه طباطبایی 1390

over the past decades a number of approaches have been applied for forecasting mortality. in 1992, a new method for long-run forecast of the level and age pattern of mortality was published by lee and carter. this method was welcomed by many authors so it was extended through a wider class of generalized, parametric and nonlinear model. this model represents one of the most influential recent d...

Journal: :iranian journal of pharmaceutical research 0
m shafiee ardestani h fathi-moghaddam

in the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in parkinsonian rats was studied using the microdialysis technique. our results showed significant differences (p<0.05) in the level of striatal glutamate between treated and non-treated damaged rats.

Journal: :iranian journal of pharmaceutical research 0
maryam zahedi department of biology, shahrekord branch, islamic azad university, shahrekord , iran mohammad reza hojjati physiology department, medical faculty, shahrekord university of medical sciences hossein fathpour of biology, shahrekord branch, islamic azad university, shahrekord , iran. zahra rabiei medical plants research center, shahrekord university of medical sciences, iran. zahra alibabaei medical plants research center, shahrekord university of medical sciences, iran. arezoo basim department of biology, shahrekord branch, islamic azad university, shahrekord , iran.

some animal models have been used to study alzheimer&apos;s disease (ad). ad is an irreversible progressive neurodegenerative disease and the most common cause of dementia. animal studies have shown that there is a relation between decrease in cholinergic functions in the nucleus basalis of meynert (nbm) and loss of learning capability and memory. the aim of this study was to investigate the ef...

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد گرمسار - پژوهشکده علوم انسانی و اجتماعی 1391

abstract the present study was conducted to investigate the effect of using model essays on the development of writing proficiency of iranian pre-intermediate efl learners. to fulfill the purpose of the study, 55 pre- intermediate learners of parsa language institute were chosen by means of administering proficiency test. based on the results of the pretest, two matched groups, one as the expe...

Journal: :iranian journal of basic medical sciences 0
mina eftekharzadeh department of anatomy, faculty of medicine, iran university of medical sciences, tehran, iran maliheh nobakht department of anatomy, faculty of medicine, iran university of medical sciences, tehran, iran cellular and molecular research center, iran university of medical sciences, tehran, iran akram alizadeh department of tissue engineering, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran mansooreh soleimani department of anatomy, faculty of medicine, iran university of medical sciences, tehran, iran cellular and molecular research center, iran university of medical sciences, tehran, iran

objective(s): intracerebral injection of bone marrow stromal cells (bmscs) is being investigated as a therapeutic tool to prevent alzheimer&apos;s disease (ad). our aim was to investigate the effects of bmscs by intrathecal injection in ad rat model. materials and methods: bmscs were obtained from the bone marrow of wistar rat and transplanted into ad rat model via intrathecal injection. the ra...

Journal: :acta medica iranica 0
gholamreza hassanzadeh department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran. and department of neuroscience, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran. amir hosseini department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran. parichehr pasbakhsh department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran. mohammad akbari department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran. massoud ghaffarpour iranian research organizations for science and technology (irost), tehran, iran. nasrin takzare department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran.

oxidative stress plays a major role in the pathogenesis of alzheimer's disease (ad) of sporadic origin. the expression of dhcr24 (seladin-1), marker for neuronal oxidative stress and degeneration, has been reported to be altered in the brains of ad patients. in the present study, we investigated the effect of trimetazidine (tmz) on the hippocampal oxidative parameters and the expression of dhcr...

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