Large well-designed clinical efficacy and safety randomized clinical trials (RCTs) are required to achieve regulatory approval of new drug treatments. The objective of this article is to make recommendations for the criteria for defining and selecting the clinical trial study population, design and efficacy outcomes measures which comprise ideal premature ejaculation (PE) interventional trial m...

In terms of advancement of life to meet the challenges new method for neuropsychopharmacological research are continually developing to ensure superior safety, accuracy, efficacy, precision etc. In this experiment, we suggested and validated two neuropsychopharmacological testing methods, these are Numeral Finding (NF) and Typo Revealing (TR) tests for the determination of attention in healthy ...

conclusions the study demonstrated that 1000 iu vitamin d supplementation for 3 months can decrease the insulin resistance in individuals with prediabetes; however, it has no significant effect on body fat mass percentage. background low serum levels of vitamin d are supposed to contribute to the incidence of diabetes; therefore, vitamin d supplementation may reduce the incidence of diabetes in...

PurposeTo assess the efficacy and safety of macitentan in pts with PH post-LVAD.MethodsSOPRANO (NCT02554903) was a double-blind, randomized, study 10 mg once-daily vs placebo. Pts were ≥18 years LVAD implanted within 90 days prior to randomization, had mean pulmonary arterial pressure (mPAP) ≥25 mmHg, artery wedge (PAWP) ≤18 mmHg vascular resistance (PVR) >3 Wood units (WU). The primary endpoin...

Placebo is the second-best remedy in Homoeopathy. In day-to-day practice certain situation arise which lead us to prescribe placebo. Beginning from case taking when patient some medicines, end of treatment homoeopathic aggravation occurs, all that time physician requires middle process placebo needed during aggravation, improvement case. Certain disease conditions like Artificial Chronic Diseas...

Dengue (pronounced DENgee) fever is a painful, debilitating mosquito-borne disease caused by any one of four closely related dengue viruses. Aim: To study effect doxycycline in bleeding manifestations fever. Materials and Methods: Randomized, double blind, placebo controlled, parallel group was conducted among 100 seropositive patients, age between 18-60 years (fulfilling inclusion exclusion cr...