conclusions there is not enough evidence to support or refute the routine use of fish oil supplements during pregnancy for the prevention or treatment of diabetes. it is suggested that further randomized controlled trials be conducted to evaluate the role of fish oil supplementation in pregnancy. context one of the most common complications of pregnancy is gestational diabetes mellitus (gdm), w...

introduction: most physicians consider abstracts to give a general idea about the full text of an article. abstracts, as summative and informative parts, contain main information of papers. they also point out the content of papers to readers. the importance of abstracts leads journals to be stricter about their structure and content. this study aimed to assess the abstracts of randomized contr...

In combination with randomization, blinding or masking is an important factor in randomized controlled trials (RCTs), particularly in trials that assess therapeutic effects. Here an attempt is made to explain blindness and why it is important. In clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...

conventional treatment for primary dysmenorrhoea has a failure rate of 20% to 25% and may be contraindicated or not tolerated by some women. herbal medicine may be a suitable alternative. the objective of the manuscript, is determine the efficacy and safety of some iranian herbal medicine for primary dysmenorrhea when compared with placebo, no treatment, and other treatment. for this target ele...

Randomized controlled trials (RCTs) are essential for evaluating the efficacy of clinical interventions, where the causal chain between the agent and the outcome is relatively short and simple and where results may be safely extrapolated to other settings. However, causal chains in public health interventions are complex, making RCT results subject to effect modification in different population...

The evidence-based medicine (EBM) movement was established to combat capricious reasoning in clinical care, particularly arguments from authority. Critique of authority and appraisal of evidence remain EBM's core values and should be revisited in this era of EBM's maturity and influence. We are now faced with a new form of under-questioned authority: evidence from well-designed and methodologic...

in combination with randomization, blinding or masking is an important factor in randomized controlled trials (rcts), particularly in trials that assess therapeutic effects. here an attempt is made to explain blindness and why it is important. in clinical trials, blinding is defined as the condition imposed on a study in which study participants, health care providers and assessors collecting o...

background: this study aimed to assess the effectiveness of topiramate, a glutamate-modulating agent, in patients with treatment-resistant obsessive-compulsive disorder (ocd) as an adjunct to serotonin reuptake inhibitors (sris). materials and methods: thirty-eight patients with refractory ocd, were randomly assigned to receive topiramate or placebo. this study was designed as a 12-week, double...

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