background substance abuse or drug addiction is one of the most important health issues in every society, which can lead to physical and mental problems. objectives this study aimed to compare the efficacy of tramadol plus gabapentin versus methadone use in the treatment of opiate withdrawal. patients and methods consenting male subjects who fulfilled the dsm-4 criteria for opiate dependence sy...

context randomized controlled trials (rcts) are important tools for evidence-based health care decisions. it is, therefore, important that they be conducted and reported with the highest possible standards. the aim of this study was to evaluate the reporting quality of the rcts published in nephrology urology monthly journal and to examine whether there was a change over time in the reporting q...

background: preterm birth is the major cause of neonatal mortality and morbidity. objective: the aim of this study was to evaluate the effect of prophylactic vaginal progesterone on decreasing preterm birth rate and neonatal complications in a high-risk population. materials and methods: a randomized, double-blind, placebo-controlled study was performed on 100 high-risk singleton pregnancies. v...

background: there are two types of primary dysmenorrhea (spasmodic and congestive) which differ from each other in terms of the time of menstrual cycle outbreak, pain quality and other symptoms. the present study aimed to determine the effect of acupressure at the sanyinjiao point (sp-6) on severity of menstrual symptoms (primary outcome) and the duration of resting time as well as the number o...

conclusions midazolam/meperidine and propofol sedation for colonoscopy have similar cardiopulmonary safety profiles and patient satisfaction levels. midazolam/meperidine can be preferred to propofol sedation due to a shorter hospital length of stay and better analgesic activity. the patient satisfaction rates were not significantly different between the groups; however, patients in the propofol...

background: hydroxymethylglutaryl‑coenzyme a reductase inhibitors (statins) are antihyperlipidemic drugs with an established efficacy in stabilizing atherosclerotic plaques and preventing atherogenesis and reducing cardiovascular events. the purpose of this study was to determine the effect of simvastatin on serum vitamin d status in dyslipidemic patients as vitamin d status has an impact on mo...

conclusions barberry supplementation reduces oxidative burden in patients with metabolic syndrome. results there was no significant difference between the groups regarding their baseline pab values (p = 0.32). a significant decrease in pab was observed in the barberry group (p = 0.022), whilst there was no significant change in the control group (p = 0.18). the magnitude of change in pab during...

conclusions the evidence that btx-a decreases ntg-induced cgrp-li and sp-li levels in trigeminovascular system suggests that btx-a attenuates migraine by suppression of neuropeptide release. btx-a injections for migraine at acupoint-sites and fixed-sites are effective. acupoint-sites btx-a administration shows more efficacy for migraine than fixed-sites application. results local btx-a injectio...