considering the importance of randomized clinical trials (rcts) in the evidence-based approach, the objective of this study was critical appraisal of reporting rcts in iranian dental journals.after adequate searching, 113 rct articles published during 2003-2010 were reviewed for quality of reporting with the consort scale. the quality of each paper was assessed on 20.although statistical analys...

background: the study aim was to reports detailed characteristics of nutrition research in field of diabetes, and recognize knowledge gap in nutrition science in diabetes in iran. methods: online databases of pubmed, web of science and scopus as well as national databases including sid, iranmedex, and magiran were searched up to 2015 to identify eligible articles. finally, 378 articles were inc...

Evidence-based medicine is a redundant term to the extent that doctors have always claimed they practiced medicine on the basis of evidence. They have, however, disagreed about what exactly constitutes legitimate evidence and how to synthesize the totality of evidence in a way that supports clinical action. Despite claims to the contrary, little progress has been made in solving this hard probl...

While randomized clinical trials (RCTs) should provide the basis for evidence-based medicine, as currently designed and analyzed, they often mislead clinical decision-making. Comparative effectiveness evaluation of two treatments [Treatment 1 (T1) versus Treatment 2 (T2)] should not be determined by the statistical effect of treatments on individual measures of outcome (benefits and/or harms), ...

OBJECTIVE The lack of a standard methodology in diagnostic research impedes adequate evaluation before implementation of constantly developing diagnostic techniques. We discuss the methodology of diagnostic research and underscore the relevance of decision analysis in the process of evaluation of diagnostic tests. STUDY DESIGN AND SETTING Overview and conceptual discussion. RESULTS Diagnost...

Well-conducted randomized clinical trials (RCT) are essential for the objective assessment of the value of new diagnostic or therapeutic medical interventions. They also will give us information about the effect of the intervention on cost and quality of life. Although the RCT was introduced 50 years ago, the requirements to ensure the best possible quality are continuously scrutinized.1–4 That...

Meta-analysis of multi-arm trials has been used increasingly in recent years. The aim of meta-analysis for multi-arm trials is to combine evidence from all possible similar studies. In this paper we propose normal approximation models by using empirical logistic transform to compare different treatments in multi-arm trials, allowing studies of both direct and indirect comparisons. Additionally,...

The REACH Forgiveness intervention has been used in psychoeducational groups, couple and individual counseling and psychotherapy, and workbooks. It has been investigated in over 20 randomized clinical trials (RCTs) worldwide. It has been accommodated to treat Christians and shown to be effective in RCTs. But most research has established it to be effective when not accommodating it to religious...

BACKGROUND Noncompliance to treatment assignment is an inevitable occurrence in randomized clinical trials (RCTs). Intention to treat (ITT) is generally considered the best method for addressing noncompliance in RCTs. Alternatives to ITT exist, including per protocol (PP), as treated (AT), and instrumental variables (IV). These three methods define participant compliance dichotomously, but part...

background: this study aimed to assess the effectiveness of topiramate, a glutamate-modulating agent, in patients with treatment-resistant obsessive-compulsive disorder (ocd) as an adjunct to serotonin reuptake inhibitors (sris). materials and methods: thirty-eight patients with refractory ocd, were randomly assigned to receive topiramate or placebo. this study was designed as a 12-week, double...