inflammatory myofibroblastic tumor (imt) in the spine or paraspinal area is extremely rare. here, we report a rare case of a 56-year-old man who had pathological-proven spinal epidural imt showing a malignancy-like infiltrative feature on mr imaging with alteration of t2 signal intensity on follow-up from slightly high to low compared with initial mr imaging. to the best of our knowledge, this ...

parathyroid adenomas, or hyperplasia may be present in patients with hypercalcemia. treatment is by surgical excision, but about 10% of the lesions may be in ectopic locations. pre-operative localization of the lesions with non-lvasive imaging, using radionuclides, ultrasound, ct, or mr], may simplify surgery, and reduce patient morbidity. however, the reports of the accuracy of the currently a...

Although the development of radiolabeled antibodies for preclinical and clinical use in PET imaging continues to mature into a widespread technique (1–4), limitations still remain: namely space, in which the antigens to which our antibody is targeting are located (intracellularly or cell surface, bound or circulating), and time, the extended period after which the imaging must take place, to al...

Parathyroid adenomas, or hyperplasia may be present in patients with hypercalcemia. Treatment Is by surgical excision, but about 10% of the lesions may be In ectopic locations. Pre-operative localization of the lesions with non-lvasive imaging, using radionuclides, ultrasound, CT, or MR], may simplify surgery, and reduce patient morbidity. However, the reports of the accuracy of the curre...

Current progress in nanomedicine has exploited the possibility of designing tumor-targeted nanocarriers being able to deliver radionuclide payloads in a site or molecular selective manner to improve the efficacy and safety of cancer imaging and therapy. Radionuclides of auger electron-, alpha-, beta-, and gamma-radiation emitters have been surface-bioconjugated or after-loaded in nanoparticles ...

This paper reviews some aspects and recent developments in the use of antibodies to target radionuclides for tumor imaging and therapy. While radiolabeled antibodies have been considered for many years in this context, only a few have reached the level of routine clinical use. However, alternative radionuclides, with more appropriate physical properties, such as lutetium-177 or copper-67, as we...

The chemical modification of oligomers such as DNA, PNA, MORF, LNA to attach radionuclides for nuclear imaging and radiotherapy applications has become a field rich in innovation as older methods are improved and new methods are introduced. This review intends to provide a brief overview of several chelators currently in use for the labeling of oligomers with metallic radionuclides such as 99m ...

The article reviews the background and current status of pretargeting for cancer imaging and therapy with radionuclides. Pretargeting procedures were introduced approximately 20 years ago as an alternative to directly radiolabeled antibodies. Because they were multistep processes, they were met with resistance but have since progressed to simple and improved procedures that could become the nex...

There has been recent and growing interest in applying Cerenkov radiation (CR) for biological applications. Knowledge of the production efficiency and other characteristics of the CR produced by various radionuclides would help in accessing the feasibility of proposed applications and guide the choice of radionuclides. To generate this information we developed models of CR production efficiency...