نتایج جستجو برای: radioimmunotherapy

تعداد نتایج: 1230  

Journal: :International Journal of Radiation Oncology Biology Physics 2022

Purpose/Objective(s) Radioimmunotherapy has become one of the most promising strategies for cancer treatment. Preclinical and clinical studies have demonstrated that antiangiogenic therapy can improve efficacy immunotherapy sensitize radiotherapy through a variety mechanisms. However, it is undefined whether angiogenesis inhibitors enhance effect radioimmunotherapy. In this study, we a...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2005
Carol M Richman Sally J Denardo Robert T O'Donnell Aina Yuan Sui Shen Desiree S Goldstein Joseph M Tuscano Ted Wun Helen K Chew Primo N Lara David L Kukis Arutselvan Natarajan Claude F Meares Kathleen R Lamborn Gerald L DeNardo

PURPOSE Although radioimmunotherapy alone is effective in lymphoma, its application to solid tumors will likely require a combined modality approach. In these phase I studies, paclitaxel was combined with radioimmunotherapy in patients with metastatic hormone-refractory prostate cancer or advanced breast cancer. EXPERIMENTAL DESIGN Patients were imaged with indium-111 (111In)-1,4,7,10-tetraaz...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2009
Heather A Jacene Ross Filice Wayne Kasecamp Richard L Wahl

UNLABELLED We retrospectively evaluated 18F-FDG PET/CT for monitoring the response of non-Hodgkin's lymphoma to radioimmunotherapy. METHODS A total of 33 clinical patients received 131I-tositumomab (n=23) or 90Y-ibritumomab tiuxetan (n=10) and underwent 18F-FDG PET/CT scans before radioimmunotherapy and at 12 wk after radioimmunotherapy. A third scan was performed on 13 patients at 24 wk afte...

2012
Erika Elgström Sophie E Eriksson Tomas G Ohlsson Jan Tennvall Rune Nilsson

UNLABELLED BACKGROUND Repeated administration of antibody-based therapies such as radioimmunotherapy depends on preserved antigen expression in tumor lesions. The purpose of this study was to evaluate whether the antigen expression in metastases observed after radioimmunotherapy differs from that of untreated primary tumors. FINDINGS 30 of the 35 Brown Norway rats with syngeneic colon carc...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010
Niklaus G Schaefer Jiemin Ma Peng Huang Judy Buchanan Richard L Wahl

UNLABELLED Radioimmunotherapy is approved by the Food and Drug Administration for CD20 antigen-positive follicular and transformed non-Hodgkin lymphoma. The goal of this study was to obtain the opinion of hematologists and medical oncologists about CD20-directed radioimmunotherapy in the United States. METHODS An e-mail-based survey with 8 questions was sent to 4,239 oncologists and hematolog...

Journal: :Indian journal of cancer 2007
Laxmi Tripathi Praveen Kumar A K Singhai

Chelates are used in cancer as cytotoxic agent, as radioactive agent in imaging studies and in radioimmunotherapy. Various chelates based on ruthenium, copper, zinc organocobalt, gold, platinum, palladium, cobalt, nickel and iron are reported as cytotoxic agent. Monoclonal antibodies labeled with radioactive metals such as yttrium-90, indium-111 and iodine-131 are used in radioimmunotherapy. Th...

Journal: :Cancer research 2005
Janina Baranowska-Kortylewicz Michio Abe Kristian Pietras Zbigniew P Kortylewicz Takashi Kurizaki Jessica Nearman Janna Paulsson R Lee Mosley Charles A Enke Arne Ostman

Whereas radioimmunotherapy of hematologic malignancies has evolved into a viable treatment option, the responses of solid tumors to radioimmunotherapy are discouraging. The likely cause of this problem is the interstitial hypertension inherent to all solid tumors. Remarkable improvements in tumor responses to radioimmunotherapy were discovered after the inclusion of STI571 in the therapy regime...

Journal: :European Journal of Nuclear Medicine and Molecular Imaging 2013

Journal: :Immunotherapy 2011

2005
Janina Baranowska-Kortylewicz Michio Abe Kristian Pietras Zbigniew P. Kortylewicz Takashi Kurizaki Jessica Nearman Janna Paulsson R. Lee Mosley Charles A. Enke Arne Östman

Whereas radioimmunotherapy of hematologic malignancies has evolved into a viable treatment option, the responses of solid tumors to radioimmunotherapy are discouraging. The likely cause of this problem is the interstitial hypertension inherent to all solid tumors. Remarkable improvements in tumor responses to radioimmunotherapy were discovered after the inclusion of STI571 in the therapy regime...

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