Five cases of radiation myelopathy were found in a total of 10,000 cases given radiotherapy from 1968 to 1977. The clinical presentation and treatment details including the total dose, treatment volume, number of fractionations, overall time, and the RET value at the spinal cord were calculated and compared with other reports on this subject. The total number of fractionations ranged from 20 to...

background: study of vascular and its secretory profile changes is an important issue in pathogenesis of radiation myelopathy. this paper reports the prostacyclin concentration changes after low-moderate doses of x-irradiation within a short period of time. materials and methods: cervical cords of wistar rats were irradiated to doses of 0.5, 1, 2, 4 and 6 gy x-rays. after 24 hours, 2 and 13 wee...

Introduction: Chemoradiation is a well-established protocol for management of localized esophageal cancer. However, some early and late toxicities are associated with this therapy. Plan evaluation in term of normal tissue complication probability (NTCP) may help clinicians to tailor this therapy more individually. Given the variety of present radiobiological models, the choice...

Radiation myelopathy is a well-known complication of irradiation therapy of neoplasms in the vicinity of the spinal cord. Most earlier authors have stressed the association of a normal myelogram and normal CSF protein level with this condition. One case of radiation myelopathy with a myelogram simulating intramedullary neoplasm and with extremely high CSF protein concentration is presented. Six...

After nothing the rarity of papers describing the pathology of delayed radiation necrosis of the spinal cord, the clinical and pathological findings from four cases are presented. The main pathological features are asymmetric demyelination of the lateral columns and to a lesser degree the posterior and anterior columns of white matter, with coagulative necrosis at the level of irradiation which...

Reactive oxygen species (ROS) have been indicated in the development of diseases such as cancer, cardiovascular diseases, degenerative diseases and ageing. An increasing body of evidence indicates an association between increased and persistent oxidative stress and the development of radiation damage in tissues such as skin, central nervous system and kidney. On the basis of the new hypothesis ...

Description : Myelopathy is the term designated to all chronic cord lesions regardless of their etiologic origins which may be vascular, inflammatory, nutritional deficiency, post-radiation etc ... but the term myelopathy is more restrictive and should be reserved for a chronic cord lesion resulting from the reduction in the dimensions of the cervical spinal canal of which the main etiology is ...

Reactive oxygen species (ROS) have been indicated in the development of diseases such as cancer, cardiovascular diseases, degenerative diseases and ageing. An increasing body of evidence indicates an association between increased and persistent oxidative stress and the development of radiation damage in tissues such as skin, central nervous system and kidney. On the basis of the new hypothesis ...