one of the applications of gold nanoparticles (gnps) in medicine is radiation dose-enhancing effect. although there are many simulations, in vitro and in vivo evidence that gnps can enhance significantly the radiation dose effect of orthovoltage beams. these beams compared with megavoltage (mv) beams, have limited applications in radiotherapy. in order to evaluate gnps radiosensitization perfor...

Introduction: Many study shown the effectiveness dose enhancement with gold nanoparticles (GNPs), especially with low-energy x-rays. Recently, proton beam radiation therapy (PBRT) has attention as a treatment for tumors. The advantage in PBRT, which releases high dose at the controllable Bragg peak position that localized for Au target and the released dose increased in depth....

objective(s): in this study we evaluate the impact of the different aspects of gold nano-particles (gnps) on the target absorptive dose enhancement factor (def) during external targeted radiotherapy with photon beams ranging from kilovolt to megavolt energies using monte carlo simulation. methods: we have simulated the interaction of photon beams with various energies of radiation using water s...

introduction in this study, we aimed to calculate dose enhancement factor (def) for gold (au) and iron (fe) nanoparticles (nps) in brachytherapy and teletherapy, using monte carlo (mc) method. materials and methods in this study, a new algorithm was introduced to calculate dose enhancement by aunps and fenps for iridium-192 (ir-192) brachytherapy and cobalt-60 (co-60) teletherapy sources, using...

Introduction In this study, we aimed to calculate dose enhancement factor (DEF) for gold (Au) and iron (Fe) nanoparticles (NPs) in brachytherapy and teletherapy, using Monte Carlo (MC) method. Materials and Methods In this study, a new algorithm was introduced to calculate dose enhancement by AuNPs and FeNPs for Iridium-192 (Ir-192) brachytherapy and Cobalt-60 (Co-60) teletherapy sources, using...

Introduction: Bismuth-based nanoparticles having high atomic number and electron density, besides of being utilized as CT contrast agent, stand as a strongly proposed method for dose enhancement in radiotherapy. Embedded nanoparticle in polymer gel dosimeter poses the first step to assess the dose enhancement capability in nanoparticles. To this end, MAGICA gel dosimeter, whic...

introduction: secondary radiation such as photoelectrons, auger electrons and characteristic radiations cause a local boost in dose for a tumor when irradiated with an external x-ray beam after being loaded with elements capable of activating the tumor, e.g.; i and gd. materials and methods:  in this investigation, the mcnpx code was used for simulation and calculation of dose enhancement facto...

introduction magnetic fields are capable of altering the trajectory of electron beams andcan be used in radiation therapy.theaim of this study was to produce regions with dose enhancement and reduction in the medium. materials and methods the ndfeb permanent magnets were arranged on the electron applicator in several configurations. then, after the passage of the electron beams (9 and 15 mev va...

background: radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like developed to date. among the special features of this type of dosimeters, is be doped with other elements or chemicals which made them appropriate for investigating of dose enhancement with contrast agents, by high atomic number. material and methods: in this study...

conclusions due to the significant reduction in the mean inactivation dose of colon cancer cells in the presence of gold nanoparticles, it seems that gnps are suitable options to achieve a new approach in order to improve radiotherapy efficiency without increasing the prescribed radiation dose. results cell survival in the presence of gnps was more than 90% and the maximum uptake of gnps was ob...