Rabeprazole sodium is a new stable pharmaceutical composition developed by us in tablet form, consisting of rabeprazole sodium as active ingredient, excipients, a separating layer and enteric coating. The manufacturing method involves pressing with preliminary wet granulation. In this work, a method was developed for the quantitative determination of rabeprazole sodium in tablets with simultane...

INTRODUCTION The present work aimed to develop and validate spectrophotometric methods for simultaneous estimation of rabeprazole sodium and aceclofenac in a pure and capsule dosage form. MATERIALS AND METHODS Method 1 is based on solving a simultaneous equation. Absorbances of rabeprazole sodium and aceclofenac were measured at their respective absorbance maximas (λ max) of 283 and 276 nm. M...

The aim of the present work was to develop simple, shorter and effective HPLC method with UV detection (285nm) and subsequent validation for the content uniformity determination of Rabeprazole Sodium in marketed tablet samples. The method uses isocratic mobile phase of 0.1M sodium phosphate buffer (pH adjusted to 6.5 with sodium hydroxide solution) and acetonitrile 65:35 compositions on reverse...

Rabeprazole sodium is a proton pump inhibitor with actions and uses similar to omeprazole. It is given orally as enteric-coated rabeprazole tablets and normally taken in the morning. For the treatment of severe ulcerative gastrooesophageal reflux desease, the usual dose is 20 mg once daily for 4 to 8 weeks. In the USA, a further 8-week course is permitted for the healing of erosive oeophagitis ...

Two simple, rapid, sensitive and accurate UVspectrophotometry (method I) and First order derivative (method II) have been developed for estimation of rabeprazole sodium in bulk and tablets. In (10% v/v) acetonitrile, the λmax of rabeprazole sodium was found to be 284 nm. The same spectrum was derivatised into first order derivative at Δλ = 2 and amplitude of the trough was recorded at 298 nm. I...

BACKGROUND & OBJECTIVE While evaluating the effectiveness of drugs used for the prophylaxis of acid aspiration of gastric contents, the impact of duodeno-gastric reflux on gastric contents has not been studied earlier. This study was carried out to evaluate the effect of preanaesthetic oral administration of sodium rabeprazole on pH and volume of gastric contents in adult patients undergoing el...

Three simple and sensitive methods were developed for the determination of a mixture of Rabeprazole sodium RB and Domperidone DP without prior separation. The first method A, isoabsorptive point comprised of measurement the total content of the mixture at their isoabsorptive point, while the content of RB was determined by measuring the first order derivative of its spectra at 231 nm, and the c...

Nitric oxide produced endogenously in vagal neurons modulates gastrointestinal motor activity as an important non-aderenergic and non-cholinergic neurotransmitter. Other than through endogenous biosynthesis, a high concentration of nitric oxide also occurs by chemical reactions within the stomach in the presence of gastric acid through the entero-salivary re-circulation of dietary nitrate. Alth...

The objective of the current study was to develop and validate a reversed-phase high-performance liquid chromatographic method for the quantitative determination of process-related impurities and degradation products of rabeprazole sodium in pharmaceutical formulation. Chromatographic separation was achieved on the Waters Symmetry Shield RP18 (250 mm × 4.6 mm) 5 μm column with a mobile phase co...

The purpose of this study was to develop and validate a new reversed phase high performance liquid chromatographic (RP-HPLC) method to quantify in vitro dissolution assay of rabeprazole sodium in pharmaceutical tablet dosage form. Method development was performed on C 18, 100 × 4.6 mm ID, and 10  μ m particle size column, and injection volume was 20  μ L using a diode array detector (DAD) to mo...