In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine system makes dihedral angles of 45.51 (7) and 44.75 (7)° with the attached 4-fluoro-phenyl ring and the pyridine ring, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 54.54 (8)° with the pyridine ring. The pyridine ring part of the pyridopyrazine ring and the pyrazine ring of two c-glide-plane-r...

In the crystal structure of the title compound, C(21)H(18)FN(5), the pyridopyrazine ring system forms dihedral angles of 33.27 (7) and 48.69 (9)° with the 4-fluoro-phenyl and pyridine ring, respectively. The dihedral angle of the 4-fluoro-phenyl and pyridine rings is 57.45 (8)°. The crystal packing is characterized by an inter-molecular N-H⋯N hydrogen bond.

In the crystal structure of the title compound, C(18)H(11)FN(4), the pyridopyrazine ring makes dihedral angles of 34.67 (7) and 52.24 (7)° with the 4-fluoro-phenyl and pyridine rings, respectively. The 4-fluoro-phenyl ring makes a dihedral angle of 59.56 (9)° with the pyridine ring.

Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, sulfonamide moiety considerable interest medicinal chemistry, as it exhibits wide range pharmacological activities. Therefore, therapeutic potential biomedical quinoxalines have been enhanced by incorporation group into their chemical framework. Th...

In the mol-ecule of the title compound, C(12)H(12)N(2)O, the quinoxaline ring is planar with an r.m.s. deviation of 0.007 (15) Å. The dihedral angle between the quinoxaline and propenyl planes is 82.1 (2)°. The crystal packing is stabilized by offset π-π stacking between the quinoxaline rings [centroid-centroid distance = 3.8832 (9) Å].

Convenient and simple procedures for the synthesis of functionalized Quinoxaline derivatives were developed via one-pot four-component reaction of o-aminoanilin, acetylenic ester, and malonyl dichloride in the presence of K2 CO3 as effective base catalyst. These compounds widely are used in various industries like paint, pharmaceutical and medicine. Quinoxaline derivatives are also part of anti...

We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.