results the administration of quercetin hydrate significantly reduced the concentration of il-13, pdgf-β, and tnf-α and increased the concentrations of inf-γ in balf. conclusions according to the experimental results, quercetin hydrate reduced the concentration of inflammatory fibrotic factors, such as il-13, pdgf-β, and tnf-α, and increased the level of the antifibrotic factor inf-γ, and the e...

background: quercetin is a strong antioxidant and long-term treatment of stz-diabetic animals and it has been shown to reduce oxidative stress.   objective: antioxidants have essential effect on spermatogenesis and sperm parameters. enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.   methods: ...

a b s t r a c t introduction: epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures. although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. new medications with novel mechanisms of action are needed to help those patients whose seizures are resistant to...

in this study, the possible involvement of l-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. addition of quercetin (0.1 µm-1 mm) caused a significant dose-dependent relaxation of noradrenaline (na)- and kcl-preconstricted rings and nifedipine attenuated this response, especially...

background and objective: diabetes mellitus is common endocrine disease cause learning and memory impairment. this study was done to evaluate the effect of quercetin on learning and memory in stz-induced diabetic rats was investigated. methods: in this experimental study, 40 male wistar rats were randomly allocated into five groups: control, quercetin - treated control, diabetic and quercetin -...

background: quercetin is a strong antioxidant and long-term treatment of stz-diabetic animals and it has been shown to reduce oxidative stress.   objective: antioxidants have essential effect on spermatogenesis and sperm parameters. enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus.   methods: ...

The effects of dietary supplementation of flavonol quercetin on both 7,12-dimethylbenz(a)anthracene (DMBA)- and N-nitrosomethylurea-induced mammary cancer in female Sprague-Dawley rats were determined. Quercetin diet was started 1 wk before intragastric instillation of DMBA (65 mg/kg of body weight) or i.v. injection of N-nitrosomethylurea (50 mg/kg of body weight) and was continued during the ...

The effects of dietary supplementation of flavonol quercetin on both 7,12-dimethylbenz(a)anthracene (I)MH.V)and A'-nitrosomethylurea-induced mammary cancer in female Sprague-Dawley rats were determined. Quercetin diet was started 1 wk before intragastric instillation of DMBA (65 mg/kg of body weight) or i.v. injection of /V-nitrosomethylurea (50 mg/kg of body weight) and was continued during th...

introduction: mental stress is one of the most important causes of the gastric ulcer. on the other hand, flavonoids such as quercetin show protective effects. the aim of this study was to investigate possible protective effect of quercetin on water restraint stress-induced ulcer in rats. methods: adult male wistar rats were divided into seven groups each containing eight animals. the first grou...

Effects of quercetin, a kind of flavonoids, on the vasodilating actions were investigated. Among the mechanisms for quercetin-induced vasodilatation in rat aorta, the involvement with the Ca(2+) activated K(+) (K(Ca)) channel was examined. Pretreatment with NE (5 microM) or KCl (60 mM) was carried out and then, the modulation by quercetin of the constriction was examined using rat aorta ring st...