introduction quantitative susceptibility mapping (qsm) is a new contrast mechanism in magnetic resonance imaging (mri). the images produced by the qsm enable researchers and clinicians to easily localize specific structures of the brain, such as deep brain nuclei. these nuclei are targets in many clinical applications and therefore their easy localization is a must. in this study, we aimed to i...

Compliance of member States to the Treaty on Non-Proliferation Nuclear Weapons is monitored through nuclear safeguards. The Passive Gamma Emission Tomography system a novel instrument developed by International Atomic Energy Agency (IAEA) for verification spent fuel stored in water pools. Advanced image reconstruction techniques are crucial obtaining high-quality cross-sectional images spent-fu...

Radium-223-dichloride ((223)RaCl₂) is a new bone-seeking calcium analogue alpha-emitter, which has obtained marketing authorization for the treatment skeletal metastases of hormone-refractory prostate cancer. The current treatment regimen is based on six consecutive doses of (223)RaCl₂ at 4 week intervals and the administered activity dose, 50 kBq/kg per cycle is based on patient weight. We ana...

Introduction: The limited spatial resolution of the gamma camera hinders the absolute quantification of planar images of small structures. The imaged structures are affected by partial volume effects (PVEs), which can spread activity and lead to underestimation of the regional distribution.  The use of optimum planar parameters reduces the impact of the limited spatial resolution of the gamma c...

Quantitative SPECT imaging of In is of growing importance in nuclear medicine applications like patient-specific radionuclide dosimetry. In this study, the quality of a Monte-Carlo based model of the imaging chain from nuclear decay to detection in a gamma camera is investigated. Important characteristics like the camera point spread function (PSF), the phantom attenuation and scatter effects a...

In oocytes, asymmetric cytokinesis represents a conserved strategy for karyokinesis during meiosis to retain ooplasmic maternal factors needed after fertilization. Given the role of gamma-tubulin in cell cycle progression and microtubule dynamics, this study focused on gamma-tubulin as a key regulator of asymmetric cytokinesis in mouse oocytes. Gamma-tubulin properties were studied using multip...

BACKGROUND A standard quantitative imaging approach to evaluate peripheral arterial disease does not exist. Quantitative tools for evaluating arteriogenesis in vivo are not readily available, and the feasibility of monitoring serial regional changes in lower extremity perfusion has not been examined. METHODS AND RESULTS Serial changes in lower extremity arteriogenesis and muscle perfusion wer...

Introduction: Theranostics, in particular, the use of radionuclides with the capability of simultaneous imaging and treatment has opened new horizons in personalized treatment planning of targeted radiation therapy. In this approach, positive beta or gamma emitters are required for imaging and alpha, beta and Auger electrons for treatment purpose. On the other hand, studies hav...