Background: The role of methadone in QTc prolongation, Torsades de Pointes (TdP) arrhythmia and sudden cardiac death has been debated. Because of widespread use of methadone in methadone maintenance treatment (MMT) centers, we aimed to study dose-related effects of methadone on QTc prolongation. Methods: In a comparative observational study, 90 patients who were under MMT were evaluated. Patien...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 background : methadone is a synthetic opioid, used in treatment of chronic pains. the current study was carried out to evaluate the qtc interval in iranian causalities (janbazan) of iran-iraq war receiving maintenance methadone treatment. methods : in 2010, one hundred war causalities in isfahan who chronically take daily dos...

BACKGROUND We investigated an association between baseline heart rate-corrected QT (QTc) interval before severe hypoglycemia (SH) and prolongation of QTc interval during SH in patients with type 2 diabetes mellitus (T2DM). METHODS Between January 2004 and June 2014, 208 patients with T2DM, who visited the emergency department because of SH and underwent standard 12-lead electrocardiography wi...

thalassemia major patients require repeated transfusions of packed cell and their lysis lead to iron deposition especially in the cardiac walls such as septum and posterior wall, so make thickening and cause cardiac disorders. in this case-control study, our object was to appoint if qt and qtc and te dispersions were predictors of cardiac disorders in thalassemia major patients or not. 34 thala...

background: the role of methadone in qtc prolongation, torsades de pointes (tdp) arrhythmia and sudden cardiac death has been debated. because of widespread use of methadone in methadone maintenance treatment (mmt) centers, we aimed to study dose-related effects of methadone on qtc prolongation. methods: in a comparative observational study, 90 patients who were under mmt were evaluated. patien...

OBJECTIVES To explore the effect of aging on cardiac toxicity specifically the interaction of age and antipsychotic drugs to alter the QT interval. METHODS THE MEDLINE DATABASES WERE SEARCHED USING THE OVIDSP PLATFORMS WITH THE SEARCH STRATEGY: "QT interval" or "QT" and "age" or "aging". The entry criteria were: over 10,000 apparently healthy individuals with data on both sexes; QT interval c...

AIMS Identification of a prolonged, corrected QT (QTc) interval in athletes may be a recommendation for disqualification from competitive sports. However, the prevalence and diagnostic significance of an isolated prolonged QTc in asymptomatic athletes without familial disease is unknown. METHODS AND RESULTS Between 1996 and 2006, 2000 elite athletes (mean age, 20.2 years) underwent 12-lead EC...

PURPOSE Ventricular repolarization is assessed using the QT interval corrected by the heart rate (QTc) via an electrocardiogram (ECG). Prolonged QTc is associated with an increased risk of arrhythmias and cardiac mortality. As there have been few reports regarding the effects of hyperthyroidism on ventricular repolarization, we studied the association between serum free thyroxine (free T4 [fT4]...

OBJECTIVES Heart-rate corrected QT (QTc) interval predicts cardiovascular mortality or all-cause mortality in the general population. Little is known about the best cut-off value of QTc interval for predicting clinical events in patients with ST-elevation myocardial infarction (STEMI). METHODS We enrolled 264 patients with STEMI who received measurement of QTc intervals at ER (QTc-ER), on day...