sudden, unexpected death may occur in apparently healthy individuals. its occurrence in psychiatric patients has raised the concern that the use of psychotropics, especially antipsychotics, may be associated with an increased risk of sudden death. this concern is maintained even though not all psychiatric patients who have succumbed to sudden death have been on psychotropics. early reports pres...

background : methadone is considered as a good choice for maintenance treatment program (mmtp) in opioid addicted individuals. qt interval prolongation was reported previously in methadone chronic usersespecially in high dose prescription. qt-interval prolongation predisposes patients to lethal dysrhythmia. this is a report of corrected qt(qtc) prolongation due to acute methadone poisoning. to ...

OBJECTIVE Typically detected via electrocardiograms (ECGs), QT interval prolongation is a known risk factor for sudden cardiac death. Since medications can promote or exacerbate the condition, detection of QT interval prolongation is important for clinical decision support. We investigated the accuracy of natural language processing (NLP) for identifying QT prolongation from cardiologist-genera...

There has been an increasing focus on drug induced QT prolongation including research on drug development and QT prolongation, following the removal of drugs due to torsades de pointes (TdP). Although this has improved our understanding of drug-induced QT prolongation there has been much less research aimed at helping clinicians assess risk in individual patients with drug induced QT prolongati...

Preventing cardiac deaths remains one of the greatest challenges in medicine in the 21st Century. There is evidence to suggest QT peak prolongation identi�ies patients who are at risk of death or non-fatal myocardial infarction (MI) [1]. The next step to reduce the risk of these patients would be to �ind out whether there are potentially treatable conditions associated with QT peak prolongation...

A prolonged QT interval is an important risk factor for ventricular arrhythmias and sudden cardiac death. QT prolongation can be caused by drugs. There are multiple risk factors for drug-induced QT prolongation, including genetic variation. QT prolongation is one of the most common reasons for withdrawal of drugs from the market, despite the fact that these drugs may be beneficial for certain p...

Background: Cirrhosis as the final stage of progressive fibrosis of liver can affect other organs such as lungs, kidneys and heart. "Cirrhotic cardiomyopathy" involves the electrophysiological abnormalities such as QT interval prolongation. We assessed correlation between corrected QT interval prolongation and severity of cirrhosis based on Child Classification in each ECG lead. ...

Drug-induced QT prolongation is a serious clinical issue in developing novel drug candidates and marketing drugs. A major cause of QT prolongation is direct inhibition of human ether-à-go-go-related gene (hERG) channels. Reduction in repolarization-related channel expression levels on plasma membranes is another mechanism that induces QT prolongation. Recently, we established a system for asses...

OBJECTIVES QT interval prolongation is prevalent among patients with Takotsubo cardiomyopathy (TC), whereas torsades de pointes (TdP) has rarely been reported in these patients. We studied all peer-reviewed reports on TC-associated QT interval prolongation and all peer-reviewed reports on TC-associated TdP to characterize the clinical circumstances leading to TdP in patients with TC. METHODS ...