Recent advances have shed new light on how the Q50 homeoproteins act in Drosophila. These transcription factors have remarkably similar and promiscuous DNA-binding specificities in vitro; yet they each specify distinct developmental fates in vivo. One current model suggests that, because the Q50 homeoproteins have distinct biological functions, they must each regulate different target genes. Ac...

A genome-wide linkage scan was performed for genes affecting submaximal exercise cardiac output (Q) and stroke volume (SV) in the sedentary state and their responses to a standardized 20-wk endurance training program. A total of 509 polymorphic markers were used, and 328 pairs of siblings from 99 white nuclear families and 102 sibling pairs from 105 black family units were available. Q and SV w...

The Langmuir-Blodgett (L-B) technique is used to coat electrode surfaces with bifunctional monolayer films that are designed to carry out two functions: passivation and gating. We demonstrate that incorporation of ubiquinone (Q50) in otherwise passivating L-B monolayer films allows us to control access to the electrode surface via a controlled number of single molecule gate sites. The electrode...

The response of an extended periodic system to a homogeneous field ~of wave-vector q50) cannot be obtained from a q50 time-dependent density functional theory ~TDDFT! calculation, because the RungeGross theorem does not apply. Time-dependent current–density functional theory is needed and demonstrates that one key ingredient missing from TDDFT is the macroscopic current. In the low-frequency li...

Alzheimer's disease (AD) is a neurodegenerative clinically characterized by progressive cognitive impairment. This work aimed to investigate the role of quercetin (Q) in treatment and protection AlCl3-induced AD rats through exploring molecular mechanisms underlying its neuroprotective therapeutic properties. In this study, male Wistar were allocated two experiments: experiment I (therapeutic e...

In northern Fennoscandia, semi-alluvial boulder-bed channels with coarse glacial legacy sediment are abundant, and due to widespread anthropogenic manipulation during timber-floating, unimpacted reference reaches rare. The landscape context of these rapids—with numerous mainstem lakes that buffer high flows connectivity in addition a regional low yield—contribute amounts fine incompetent transp...

Mutants of engrailed homeodomain (HD) that retain DNA-binding activity were isolated using a phage display selection. This selection was used to enrich for active DNA-binding clones from a complex library consisting of over a billion members. A more focused library of mutant homeodomains consisting of all possible amino acid combinations at two DNA-contacting residues (I47 and Q50) was construc...

s and p plasmons in coaxial carbon nanotubes and multishell fullerenes are modeled in analogy with coupled collective excitations in finite, layered, two-dimensional-electron-gas, planar semiconductor superlattices. The curvature of the surface of these complex carbon clusters plays an important role in shaping the dimensionality ~one dimensional, two dimensional, or three dimensional! of the p...

Introduction Single Molecule, Real-Time (SMRT) DNA sequencing achieves highly accurate sequencing results, exceeding 99.999% (Q50) accuracy, regardless of the DNA's sequence context or GC content. This is possible because SMRT Sequencing excels in all three categories that are relevant when considering accuracy in DNA sequencing: 1. Consensus accuracy 2. Sequence context bias 3. Mappability of ...

We present a basic exogenous growth model with two consumption goods that differ as regards their contributions to environmental pollution. Allowing for habit formation of the polluting good, we show under which conditions habit formation raises the consumption of the clean good relative to the dirty one in the competitive economy. Further, we demonstrate when habit formation generates a lower ...