A new series of indole-based pyranoquinoline derivatives P1-24 has been synthesized by a one-pot cyclocondensation reaction of 2-(4-substituted)phenyl-N-allyl-indole-3-carbaldehydes 1a-d; active methylenes 2a-c; and 4-hydroxy-1-substituted quinolin-2(1H)-one 3a-b catalysed by an organocatalyst tetra-n-butylammonium fluoride (TBAF) in aqueous ethanol. The easy experimental procedure of the react...

A new and imaginative technique for the synthesis of substituted pyranoquinoline via Algar Flyn Oyamanda oxidation cyclization approach has been achieved by hydrogen peroxide and sodium hydroxide catalyzed of quinoline chalcone with intramolecular cyclization to formed pyranoquinoline. In this reaction, two new C-C bonds were formed in a one step with high atom economy. The possible reaction pa...

The plant family Rutaceae is known [1, 2] to be a prolific source of furoquinoline and pyranoquinoline alkaloids. Along with them acridine alka­ loids [3, 4] have also been isolated from several members of the same plant family. Recently furanfused acridine systems such as 1 l-methylfuro(2,3-c)acridan-6(l lH)one (1) have also been reported [5-7] to occur in some rutaceous plants. Typical exampl...

Pyranoquinoline alkaloids, which possess inter­ esting pharmacological properties are known [1, 2] to occur in the plant family Rutaceae. The alka­ loids, khaplofoline (1) and ribalinine (2), isolated respectively from Haplophyllum foliosum (Vved) [3] and Balfourodendron riedelianum [4], members of the rutaceae, are structurally proven to be of pyrano [2,3-b]quinoline systems. Several reports h...

eggshell was found to be a versatile heterogeneous catalyst for the synthesis of pyrano[3,2-c]quinoline derivatives in good yields. this protocol has the advantages of environmental friendliness, short reaction time, low cost and convenient operation.

Nedocromil sodium (FPL 59002) is a pyranoquinoline dicarboxylic acid that has been developed for the management of bronchial asthma. We report the results of a double blind group comparative trial in which the disodium salt of nedocromil delivered by pressurised aerosol and a placebo were compared in the management of patients with a diagnosis of bronchial asthma who entered the double blind pe...

against several kind of sickness including cancer, gastric ulcers, dyspepsia and also useful as an antibacterial and antiinflammatory. Sesquiterpenes, triterpenes, quinone-methide and sesquiterpene pyridine alkaloids have been identified in these species. Maytenus obtusifolia MART. is a plant found in many states of the Northeast and South-east of Brazil, which is used in traditional medicine f...

Nedocromil sodium is a pyranoquinoline derivative that has been developed for the treatment of asthma. We report the results of a double blind randomised study of the effect of two doses of nedocromil sodium (2 and 4 mg) and matched placebo, delivered by metered dose pressurised aerosol, on bronchoconstriction induced by sulphur dioxide in six asthmatic subjects. Nedocromil sodium had no effect...