in order to enhance in vitro dissolution and content uniformity of poorly soluble drug glimepiride by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using peg 6000 and pvp k25 (as carrier). eight batches (f1-f8) were prepared by factorial design (23) by taking three factors i.e. the concentration of: dr...

Flurbiprofen is a water insoluble non-steroidal anti inflammatory drug and belongs to BCS Class II categories. Solid dispersion is a technique by which we can improve it water solubility. By the help of fast dissolving formulation we can evaluate the effectiveness of solid dispersion. In this research work the solid dispersion of flurbiprofen with polymer like PVP K25, PVP K30, PVP K29-32, and ...

The partitioning of lysozyme and extraction yield in an aqueous two-phase system containing Poly Vinyl Pyrrolidone (PVP) K25 and potassium phosphate were investigated as a function of weight percent of salt and PVP in the feed, temperature, and pH. To investigate partitioning behavior, the central composite design was considered using a quadratic model. According to the results of the model...

Orodispersible drug formulations are a current trend in the pharmaceutical industry, mostly intended for pediatric and geriatric patients. Oral lyophilizates solid forms, either to be placed mouth or dispersed (or dissolved) water before administration. The correct excipient composition is prerequisite provide with appropriate visual appearance disintegration time. Typically, they composed of b...

      In order to enhance in vitro dissolution and content uniformity of poorly soluble drug glimepiride by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using PEG 6000 and PVP K25 (as carrier). Eight batches (F1-F8) were prepared by Factorial design (23) by taking three ...

An important issue for chromatin remodeling complexes is how their bromodomains recognize particular acetylated lysine residues in histones. The Rsc4 subunit of the yeast remodeler RSC contains an essential tandem bromodomain (TBD) that binds acetylated K14 of histone H3 (H3K14ac). We report a series of crystal structures that reveal a compact TBD that binds H3K14ac in the second bromodomain an...

Neuronal activity promotes the survival of cerebellar granule neurons (CGNs) during the postnatal development of cerebellum. CGNs that fail to receive excitatory inputs will die by apoptosis. This process could be mimicked in culture by exposing CGNs to either a physiological concentration of KCl (5 mm or K5) plus N-methyl-d-aspartate (NMDA) or to 25 mm KCl (K25). We have previously described t...

The goal of the present study was to develop inclusion complexes and polymers dispersions ramipril prepared by physical mixing, kneading, co-evaporation, solvent evaporation methods enhance drug solubility dissolution rate, thereby reduce dose side effects using selected hydrophilic carriers such as β-CD, PVP-K25, PEG 4000, HPMC K100M. formulations were characterized for in-vitro release studie...

We used regression analyses of water samples from 18 lakes, nine rivers, and one spring in Ethiopia to (a) test the hypothesis that water bodies of relatively higher salinity (K25 > 1000 hiS cm -1) have a different conductivity to salinity relationship than waters of lower salinity (K25 < 1000 taS cm-1), and (b) develop models to predict total cations and salinity from conductivity that can be ...