نتایج جستجو برای: pvmsp

تعداد نتایج: 47  

Journal: :Infection and immunity 2004
Suraksha Sachdeva Gul Ahmad Pawan Malhotra Paushali Mukherjee V S Chauhan

The 42- and 19-kDa C-terminal fragments of merozoite surface protein 1 (MSP-1(42) and MSP-1(19), respectively) are both promising blood-stage vaccine candidate antigens. At present, it is not clear which of the two antigens will be more suitable for inclusion in a cocktail malaria vaccine. In the present study, we expressed the two C-terminal fragments of Plasmodium vivax MSP-1 (PvMSP-1) in an ...

Journal: :Clinical and vaccine immunology : CVI 2007
Melissa S Bastos Mônica da Silva-Nunes Rosely S Malafronte Erika Hellena E Hoffmann Gerhard Wunderlich Sandra L Moraes Marcelo U Ferreira

Merozoite surface protein 1 of Plasmodium vivax (PvMSP-1), a major target for malaria vaccine development, contains six highly polymorphic domains interspersed with conserved sequences. Although there is evidence that the sequence divergence in PvMSP-1 has been maintained over 5 million years by balanced selection exerted by the host's acquired immunity, the variant specificity of naturally acq...

2015
Hadi MIRAHMADI Adel SPOTIN Shirzad FALLAHI Niloofar TAGHIPOUR Habibollah TURKI Seyyed Javad SEYYED TABAEI

BACKGROUND Carboxy-terminal 42 kDa region of Plasmodium vivax merozoite surface protein-1 is considered as an important antigen in blood stage. Since, this region has been observed to be polymorphic among isolates of P. vivax, it is significant to survey on different regions of this antigen in various areas of the world. METHODS In the present study, the genetic diversity of cloned PvMSP-142 ...

Journal: :Infection and immunity 2001
S Dutta L A Ware A Barbosa C F Ockenhouse D E Lanar

The Plasmodium vivax merozoite surface protein 1 (MSP-1) 42-kDa fragment (PvMSP-1 p42) is a promising vaccine candidate antigen against the blood stage of the malarial parasite. We have developed a process for the production of this vaccine target, keeping in mind its use in human volunteers. A novel strain, Origami(DE3), of Escherichia coli with mutations in the glutathione and thioredoxin red...

2013
Amanda R. Bitencourt Elaine C. Vicentin Maria C. Jimenez Ricardo Ricci Juliana A. Leite Fabio T. Costa Luis C. Ferreira Bruce Russell François Nosten Laurent Rénia Mary R. Galinski John W. Barnwell Mauricio M. Rodrigues Irene S. Soares

A recent clinical trial in African children demonstrated the potential utility of merozoite surface protein (MSP)-3 as a vaccine against Plasmodium falciparum malaria. The present study evaluated the use of Plasmodium vivax MSP-3 (PvMSP-3) as a target antigen in vaccine formulations against malaria caused by P. vivax. Recombinant proteins representing MSP-3α and MSP-3β of P. vivax were expresse...

Journal: :Memorias do Instituto Oswaldo Cruz 2008
Fabio Aníbal Cristiano Manuel Alberto Pérez Rubén Santiago Nicholls Angela Patricia Guerra

We evaluated the Plasmodium vivax polymorphism by studying the Pvmsp-3alpha gene's polymorphic region by PCR-RFLP in 55 samples from patients living in Tierralta, Colombia. Three different sizes of the Pvmsp-3 alpha gene were found, type A (1,900 bp), type B (1,500 bp) and type C (1,100 bp); most of the samples were type A (96.4 %). The Pvmsp-3alpha gene exhibited high polymorphism. Seven restr...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Chaturong Putaporntip Somchai Jongwutiwes Naoko Sakihama Marcelo U Ferreira Weon-Gyu Kho Akira Kaneko Hiroji Kanbara Tetsuya Hattori Kazuyuki Tanabe

The organization and allelic recombination of the merozoite surface protein-1 gene of Plasmodium vivax (PvMsp-1), the most widely prevalent human malaria parasite, were evaluated in complete nucleotide sequences of 40 isolates from various geographic areas. Alignment of 31 distinct alleles revealed the mosaic organization of PvMsp-1, consisting of seven interallele conserved blocks flanked by s...

2014
Julia C Cutts Rosanna Powell Paul A Agius James G Beeson Julie A Simpson Freya J I Fowkes

BACKGROUND Identifying Plasmodium vivax antigen-specific antibodies associated with P. vivax infection and protective immunity is key to the development of serosurveillance tools and vaccines for malaria. Antibody targets of P. vivax can be identified by seroepidemiological studies of individuals living in P. vivax-endemic areas, and is an important strategy given the limited ability to culture...

Journal: :Memorias do Instituto Oswaldo Cruz 2011
Ricardo Souza Ribeiro Luisa Ladeira Antonio Mauro Rezende Cor Jesus Fernandes Fontes Luzia Helena Carvalho Cristiana Ferreira Alves de Brito

Reliable molecular markers are essential for a better understanding of the molecular epidemiology of Plasmodium vivax, which is a neglected human malaria parasite. The aim of this study was to analyze the genetic diversity of P. vivax isolates from the Brazilian Amazon using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of the highly polymorphic merozoit...

2017
Wei Ruan Ling-ling Zhang Yan Feng Xuan Zhang Hua-liang Chen Qiao-yi Lu Li-nong Yao Wei Hu

BACKGROUND Plasmodium vivax remains a potential cause of morbidity and mortality for people living in its endemic areas. Understanding the genetic diversity of P. vivax from different regions is valuable for studying population dynamics and tracing the origins of parasites. The PvMSP-1 gene is highly polymorphic and has been used as a marker in many P. vivax population studies. The aim of this ...

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