neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. it manifests as dic and extensive subcutaneous thrombosis. the condition is often fatal unless there is prompt diagnosis, and judicious therapy. the most important causes of this condition are infections and congenital deficiency of anticoagulant proteins c and s.in the case of pc (p...

Neonatal purpura fulminans is a rare and life threatening disease that can be inherited or acquired in etiology. It manifests as DIC and extensive subcutaneous thrombosis. The condition is often fatal unless there is prompt diagnosis, and judicious therapy. The most important causes of this condition are infections and congenital deficiency of anticoagulant proteins C and S.In the case of PC (p...

henoch-schönlein purpura nephritis and iga nephropathy are currently considered to be different clinical presentations of the same disease. there is need for a reliable proven, morphologic classification that can help clinicians more accurately formulate treatment strategies for patients with henoch-schönlein purpura nephritis. considering that henoch-schönlein purpura nephritis and iga nephrop...

INTRODUCTION Henoch-Schönlein purpura is an immunoglobulin A-mediated, small vascular inflammatory disease that can be associated with palpable purpura, arthralgia, abdominal pain, or nephritis. The presence of purpura facilitates the diagnosis of Henoch-Schönlein purpura at the onset of associated symptoms, whereas the absence of purpura makes the diagnosis challenging. It is important to diag...

Henoch-Schönlein purpura is the most common systemic vasculitis of childhood. In the majority of children, the outcome of Henoch-Schönlein purpura is excellent with spontaneous resolution of symptoms and signs. However, a small subset of patients will develop long-term sequelae in the form of chronic kidney disease. While the clinical presentation and diagnosis of Henoch-Schönlein purpura is st...

Cases of purpura in the newborn have been recorded fairly frequently, and Robson and Walker (1951) have recently reviewed the literature of some 52 cases. Three types of congenital purpura are recognized: (1) Purpura when the mother is affected; (2) purpura when the mother is normal; (3) purpura associated with hypoplasia of the bone marrow. The essential characteristics in the diagnosis of idi...

1. The purpura-producing principle of Pneumococcus is non-antigenic in the sense that it does not stimulate the formation of antibodies. 2. White mice acquire an increased resistance to purpura as a result of repeated injections of toxic doses of the purpura substance. 3. The serum of rabbits immunized with the purified purpura principle, with "S" and "R" strains of Pneumococcus or with cell ex...

Thromb Haemost 2005;3:1432-6. 4. Dashe JS, Ramin SM, Cunningham FG. The long-term consequences of thrombotic microangiopathy (thrombotic thrombocytopenic purpura and hemolytic uremic syndrome) in pregnancy. Obstet Gynecol 1998;91:662-8. 5. Miner PE, Nutt RL, Thomas ME. Thrombotic thrombocytopenic purpura occurring in pregnancy. Am J Obstet Gynecol 1955;70:611-7. 6. Weiner CP. Thrombotic microan...

Henoch-Schönlein purpura nephritis and IgA nephropathy are currently considered to be different clinical presentations of the same disease. There is need for a reliable proven, morphologic classification that can help clinicians more accurately formulate treatment strategies for patients with Henoch-Schönlein purpura nephritis. Considering that Henoch-Schönlein purpura nephritis and IgA nephrop...

Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report case TTP in Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features resolved soon after clopidogrel withdrawn. Clopidogrel cardio-protective anti-platelet drug used CKD patients at risk dyspepsia. However, its potential to cause should be recognized and cons...