in spite of the existing reports on behavioural and biochemical changes related to the cerebellum due to noise stress, not much is known about the effect of noise stress on the neuronal changes in the cerebellum. the present study aims at investigating the effects from one week noise exposure on granule cell number and purkinje cell volume within the neonate rat cerebellum. 15-day-old male wist...

conclusions considering that neuronal function highly depends on environmental conditions, any adverse alteration may affect the function and morphology of neurons. in this regard, our results showed the adverse effects of protein malnutrition on the morphology of the purkinje cells of cerebellum. results the low-protein group did not gain weight as much as control group (p < 0.05). the diamete...

objective: the purpose of this study was to investigate the role of fast inactivating (ia) voltage dependent potassium channels in shaping the discharge activity of cerebellar purkinje cells (pcs) in ataxic rats. materials and methods: male sprauge-dawley rats (40-60 g) were used in this study. ataxia was induced via single i.p. injection of 3-acethylpyridine (65 mg/kg). four days following ind...

objective: intra-peritoneal administration of riluzole has been shown to preserve the membrane properties and firing characteristics of purkinje neurons in a rat model of cerebellar ataxia induced by 3-acetylpyridine (3-ap). however, the exact mechanism(s) by which riluzole restores the normal electrophysiological properties of purkinje neurons is not completely understood. changes in the condu...

In spite of the existing reports on behavioural and biochemical changes related to the cerebellum due to noise stress, not much is known about the effect of noise stress on the neuronal changes in the cerebellum. The present study aims at investigating the effects from one week noise exposure on granule cell number and Purkinje cell volume within the neonate rat cerebellum.15-day-old male Wista...

Introduction:&nbsp;Diabetes mellitus is associated with nervous system alterations in both human and animal models. This study was done to determine the effect of gestational diabetes on the Purkinje and granular cells in the cerebellum of rat offspring.&nbsp; Methods: 10 Wistar rats Dams were randomly allocated in control and diabetic group. The experimental group received 40 mg/kg/body wei...

Introduction: Beta-carboline alkaloids of&nbsp;P. harmala&nbsp;are shown to have immune-modulatory effects in several studies. Extracts of this plant have significant anti-inflammatory effect via the inhibition of some inflammatory mediators including PGE2 and TNF-&alpha;. In postmortem studies, structural alterations to the cerebellum have been recognized, including Purkinje cell loss being re...

introduction: diabetes mellitus is associated with nervous system alterations in both human and animal models. this study was done to determine the effect of gestational diabetes on the purkinje and granular cells in the cerebellum of rat offspring.  methods: 10 wistar rats dams were randomly allocated in control and diabetic group. the experimental group received 40 mg/kg/body weight of strept...

introduction: purkinje cell (pc) output displays a complex firing pattern consisting of high frequency sodium spikes and low frequency calcium spikes, and disruption in this firing behavior may contribute to cerebellar ataxia. riluzole, neuroprotective agent, has been demonstrated to have neuroprotective effects in cerebellar ataxia. here, the spectral analysis of pcs firing in control, 3-acety...