in spite of the existing reports on behavioural and biochemical changes related to the cerebellum due to noise stress, not much is known about the effect of noise stress on the neuronal changes in the cerebellum. the present study aims at investigating the effects from one week noise exposure on granule cell number and purkinje cell volume within the neonate rat cerebellum. 15-day-old male wist...

objective: intra-peritoneal administration of riluzole has been shown to preserve the membrane properties and firing characteristics of purkinje neurons in a rat model of cerebellar ataxia induced by 3-acetylpyridine (3-ap). however, the exact mechanism(s) by which riluzole restores the normal electrophysiological properties of purkinje neurons is not completely understood. changes in the condu...

objective: the purpose of this study was to investigate the role of fast inactivating (ia) voltage dependent potassium channels in shaping the discharge activity of cerebellar purkinje cells (pcs) in ataxic rats. materials and methods: male sprauge-dawley rats (40-60 g) were used in this study. ataxia was induced via single i.p. injection of 3-acethylpyridine (65 mg/kg). four days following ind...

conclusions considering that neuronal function highly depends on environmental conditions, any adverse alteration may affect the function and morphology of neurons. in this regard, our results showed the adverse effects of protein malnutrition on the morphology of the purkinje cells of cerebellum. results the low-protein group did not gain weight as much as control group (p < 0.05). the diamete...

Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. This study aimed at determining the DM toxicity and anti-apoptotic effect of OE pretreatment in cerebellar Purkinje neurons. Materials and Methods: Rats were randomly divided into four groups a...

background: deltamethrin (dm) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. there is accumulating evidence that oleuropein (oe) has anti-apoptotic effect. this study aimed at determining the dm toxicity and anti-apoptotic effect of oe pretreatment in cerebellar purkinje neurons. materials and methods: rats were randomly divided into four groups as f...

In spite of the existing reports on behavioural and biochemical changes related to the cerebellum due to noise stress, not much is known about the effect of noise stress on the neuronal changes in the cerebellum. The present study aims at investigating the effects from one week noise exposure on granule cell number and Purkinje cell volume within the neonate rat cerebellum.15-day-old male Wista...

Conduction system pacing (CSP), delivered through His bundle (HBP) or left (LBP), is a novel effective treatment for patients with proximal branch block (LBBB). The presence of septal scar known to affect response CSP, but the effect conduction properties on CSP has never been investigated. To quantify scarred myocardium and Purkinje velocity (CV) using computational modelling. We computed vent...

Introduction: Beta-carboline alkaloids of&nbsp;P. harmala&nbsp;are shown to have immune-modulatory effects in several studies. Extracts of this plant have significant anti-inflammatory effect via the inhibition of some inflammatory mediators including PGE2 and TNF-&alpha;. In postmortem studies, structural alterations to the cerebellum have been recognized, including Purkinje cell loss being re...