background: to manage relapsing‑remitting multiple sclerosis (ms) in the course of acute exacerbations, methylprednisolone (mp) (medrol or solu‑medrol), has the ability to lock the injured blood‑brain barrier and decrease irritation in the central nervous system. the aim of this preliminary study was to investigate the frequency and time interval related to mp pulse therapy in patients with ms....

introduction application of near-infrared absorbing nanostructures can induce hyperthermia, in addition to providing more efficient  photothermal effects. gold-gold sulfide (ggs) is considered as one of these nanostructures. this study was performed on a tissue-equivalent optical-thermal phantom to determine the temperature profile in the presence and absence of ggs and millisecond pulses of a ...

  intravenous glucocorucoid pulse therapy is a common treatment for immunologically origin diseases but it can not be considered a completely bening treatment.the effects of long term administration of glucocorticoids on calcium and phosphorus metabolism are week known ,but is less in known about the effect of pluse therapy.the purpose of this study was to investigate the effect of methylpredn...

The efficacy of single-agent chemotherapy for patients with low risk gestational trophoblastic neoplasia (LRGTN) with methotrexate or dactinomycin is well established, but efforts continue to reduce the toxicity, the patients time and cost of treatment. In a randomized clinical trial, we evaluated and compared the efficacy, toxicity and cost effectiveness of pulse-methotrexate versus pulse-dact...

Background: Lichen planus is a common dermatological condition. Many treatment options have been discussed in literature, each with its own risk profile. Betamethasone pulse therapy is one of the effective therapies mentioned.The objective of this study was to find out whether oral betamethasone mini pulse therapy is effective in lichen planus.Methods: A total of 40 pat...

introduction patients with hepatitis c are commonly treated with combination of pegylated interferon alfa-2a and ribavirin. less than 1% of patients receiving this treatment experience very uncommon ophthalmological side effects such as optic neuropathy and vision disorder, which are usually subclinical, mild and reversible, not requiring the withdrawal of the treatment. retinopathy is the most...

Intravenous supra-pharmacological doses of corticosteroids are used in various inflammatory and autoimmune conditions because they are cumulatively less toxic than sustained steroid treatment at lower quantitative dosage. Their action is supposed to be mediated through non-genomic actions within the cell. Common indications for use in children include steroid resistant and steroid dependent nep...